Vertex Pharmaceuticals Incorporated (VRTX)

US — Healthcare Sector
Peers: REGN  CRSP  NVO  SRPT  NTLA  BIIB  INCY  BMRN  ILMN 

Automate Your Wheel Strategy on VRTX

With Tiblio's Option Bot, you can configure your own wheel strategy including VRTX - and automate your put writes, covered calls, and full wheel strategy. Just connect one of the supported brokerages: tastytrade, Schwab, TradeStation or Tradier and go.

Start Your Free Trial Now

Key Metrics & Ratings

  • symbol VRTX
  • Rev/Share 43.2063
  • Book/Share 64.2129
  • PB 7.4678
  • Debt/Equity 0.1
  • CurrentRatio 2.6456
  • ROIC -0.128

 

  • MktCap 123141865410.0
  • FreeCF/Share -4.8968
  • PFCF -97.887
  • PE -124.574
  • Debt/Assets 0.0721
  • DivYield 0
  • ROE -0.0625

 

  • Rating C
  • Score 2
  • Recommendation Sell
  • P/E Score 1
  • DCF Score 4
  • P/B Score 1
  • D/E Score 3

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Downgrade VRTX Wolfe Research Outperform Peer Perform -- -- May 7, 2025
Downgrade VRTX Leerink Partners Outperform Market Perform -- $503 May 6, 2025
Resumed VRTX Cantor Fitzgerald -- Overweight -- $535 April 22, 2025
Upgrade VRTX Canaccord Genuity Sell Hold $408 $424 Feb. 12, 2025
Upgrade VRTX Canaccord Genuity Sell Hold -- -- Feb. 11, 2025
Downgrade VRTX Wells Fargo Overweight Equal Weight -- $460 Jan. 30, 2025
Reiterated VRTX H.C. Wainwright -- Buy $600 $535 Dec. 20, 2024
Downgrade VRTX Oppenheimer Outperform Perform -- -- Dec. 19, 2024
Upgrade VRTX Jefferies Hold Buy $500 $550 Dec. 9, 2024
Initiation VRTX Scotiabank -- Sector Perform -- -- Oct. 16, 2024

News

Vertex: Latest Casgevy Data Highlights Efficacy Amid Slow Commercial Launch
VRTX
Published: July 09, 2025 by: Seeking Alpha
Sentiment: Positive

Vertex Pharmaceuticals Incorporated remains a Buy: its cystic fibrosis franchise ensures robust revenue for a decade, and its pipeline offers multiple long-term growth drivers. Casgevy's long-term data shows durable, life-changing benefits for SCD and TDT patients, but adoption is limited by a complex, intensive treatment process. Current Casgevy revenues are modest, but improvements to preconditioning and in-vivo approaches could unlock blockbuster potential by 2030.

Read More
image for news Vertex: Latest Casgevy Data Highlights Efficacy Amid Slow Commercial Launch
Healthy Returns: Medicaid cuts in Trump's megabill may affect some drugmakers more than others
BMY, GILD, JNJ, NVO, PFE, RHHBY, VRTX
Published: July 08, 2025 by: CNBC
Sentiment: Negative

Trump's "big beautiful" bill will also affect the pharmaceutical industry, while AI startups have pulled in the majority of digital health funding this year.

Read More
image for news Healthy Returns: Medicaid cuts in Trump's megabill may affect some drugmakers more than others
Vertex Pharmaceuticals Incorporated (VRTX) is Attracting Investor Attention: Here is What You Should Know
VRTX
Published: July 02, 2025 by: Zacks Investment Research
Sentiment: Positive

Zacks.com users have recently been watching Vertex (VRTX) quite a bit. Thus, it is worth knowing the facts that could determine the stock's prospects.

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) is Attracting Investor Attention: Here is What You Should Know
Vertex Gets EU Nod for New Cystic Fibrosis Drug Alyftrek
VRTX
Published: July 02, 2025 by: Zacks Investment Research
Sentiment: Positive

VRTX secures EU approval for Alyftrek, a next-in-class triple combination regimen for treating people with CF aged six years and older.

Read More
image for news Vertex Gets EU Nod for New Cystic Fibrosis Drug Alyftrek
Vertex Down Around 9% in Three Months: Should You Buy, Sell or Hold the Stock?
VRTX
Published: June 30, 2025 by: Zacks Investment Research
Sentiment: Neutral

VRTX slips 9% in three months on slow new drug uptake and pipeline hiccups, but CF strength and 2025 growth offer a reason to hold.

Read More
image for news Vertex Down Around 9% in Three Months: Should You Buy, Sell or Hold the Stock?
Vertex and Ono Pharmaceutical Announce Strategic Agreement to Develop and Commercialize Povetacicept in Japan and South Korea
VRTX
Published: June 23, 2025 by: Business Wire
Sentiment: Neutral

BOSTON & OSAKA, Japan--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) and Ono Pharmaceutical Co., Ltd. (OTCMKTS: OPHLY) today announced an exclusive collaboration and license agreement for the development and commercialization of Vertex's povetacicept in Japan and South Korea. Povetacicept is a recombinant fusion protein therapeutic and dual antagonist of the BAFF (B cell activating factor) and APRIL (a proliferation inducing ligand) cytokines with best-in-class potential b.

Read More
image for news Vertex and Ono Pharmaceutical Announce Strategic Agreement to Develop and Commercialize Povetacicept in Japan and South Korea
Vertex Pharmaceuticals Incorporated (VRTX) Presents at American Diabetes Association (ADA) 85th Scientific Sessions Conference Transcript
VRTX
Published: June 22, 2025 by: Seeking Alpha
Sentiment: Neutral

Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX ) American Diabetes Association (ADA) 85th Scientific Sessions Conference June 20, 2025 8:15 PM ET Company Participants James Markmann - Corporate Participant Michael Rickels - Corporate Participant Felicia Pagliuca - Corporate Participant Susie Lisa - Senior Vice President of Investor Relations Conference Call Participants Adam Ferrari - JPMorgan Chase & Co, Research Division Bryan Russell Dollinger - Leerink Partners LLC, Research Division Dina Elmonshed - Jefferies LLC, Research Division Jarwei Fang - Unidentified Company Liisa Ann Bayko - Evercore ISI Institutional Equities, Research Division Malcolm Hoffman - BMO Capital Markets Equity Research Mohit Bansal - Wells …

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) Presents at American Diabetes Association (ADA) 85th Scientific Sessions Conference Transcript
Here's Why Vertex Pharmaceuticals (VRTX) Fell More Than Broader Market
VRTX
Published: June 20, 2025 by: Zacks Investment Research
Sentiment: Negative

In the closing of the recent trading day, Vertex Pharmaceuticals (VRTX) stood at $440.87, denoting a -1.68% move from the preceding trading day.

Read More
image for news Here's Why Vertex Pharmaceuticals (VRTX) Fell More Than Broader Market
Vertex Pharmaceuticals Incorporated (VRTX) Is a Trending Stock: Facts to Know Before Betting on It
VRTX
Published: June 19, 2025 by: Zacks Investment Research
Sentiment: Positive

Vertex (VRTX) has been one of the stocks most watched by Zacks.com users lately. So, it is worth exploring what lies ahead for the stock.

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) Is a Trending Stock: Facts to Know Before Betting on It
Investors Heavily Search Vertex Pharmaceuticals Incorporated (VRTX): Here is What You Need to Know
VRTX
Published: June 04, 2025 by: Zacks Investment Research
Sentiment: Positive

Vertex (VRTX) has received quite a bit of attention from Zacks.com users lately. Therefore, it is wise to be aware of the facts that can impact the stock's prospects.

Read More
image for news Investors Heavily Search Vertex Pharmaceuticals Incorporated (VRTX): Here is What You Need to Know
Vertex Pharmaceuticals Incorporated (VRTX) Bernstein 41st Annual Strategic Decisions Conference (Transcript)
VRTX
Published: May 30, 2025 by: Seeking Alpha
Sentiment: Neutral

Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX ) Bernstein 41st Annual Strategic Decisions Conference May 30, 2025 8:00 AM ET Company Participants Reshma Kewalramani - President & CEO Conference Call Participants Will Pickering - Bernstein Will Pickering All right. Well, I think we can get started.

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) Bernstein 41st Annual Strategic Decisions Conference (Transcript)
3 Top Growth Stocks to Buy in the Second Half of 2025
AMZN, META, VRTX
Published: May 26, 2025 by: The Motley Fool
Sentiment: Positive

Believe it or not, but we're not far away from being halfway through the year. Time flies when you're having fun -- and when you're not having fun, too.

Read More
image for news 3 Top Growth Stocks to Buy in the Second Half of 2025
Vertex: Continuing To Dominate In CF, But What About Its Pain Pipeline?
VRTX
Published: May 23, 2025 by: Seeking Alpha
Sentiment: Positive

Vertex Pharmaceuticals Incorporated remains a buy despite recent share price weakness, supported by its dominant cystic fibrosis franchise and robust late-stage pipeline. Alyftrek's launch extends Vertex's CF leadership, patent life, and addressable market, while Casgevy and Journavx add new growth avenues. VRTX valuation is justified by stable CF cash flows, a strong balance sheet, proven management, and a diversified pipeline with multiple near-term catalysts.

Read More
image for news Vertex: Continuing To Dominate In CF, But What About Its Pain Pipeline?
Final Trades: Vertex Pharma, Palantir, Wynn Resorts and Microsoft
MSFT, PLTR, VRTX, WYNN
Published: May 09, 2025 by: CNBC Television
Sentiment: Neutral

The Investment Committee give you their top names to watch for the second half.

Read More
image for news Final Trades: Vertex Pharma, Palantir, Wynn Resorts and Microsoft
Vertex Pharmaceuticals Incorporated (VRTX) is Attracting Investor Attention: Here is What You Should Know
VRTX
Published: May 09, 2025 by: Zacks Investment Research
Sentiment: Positive

Recently, Zacks.com users have been paying close attention to Vertex (VRTX). This makes it worthwhile to examine what the stock has in store.

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) is Attracting Investor Attention: Here is What You Should Know
VRTX Stock Down as Q1 Sales of New Drugs Miss Expectations
VRTX
Published: May 07, 2025 by: Zacks Investment Research
Sentiment: Negative

Sales from VRTX's new drugs, Casgevy, Alyftrek and Journavx, in Q1 fell short of investor expectations.

Read More
image for news VRTX Stock Down as Q1 Sales of New Drugs Miss Expectations
Vertex On Track To Significantly Improve Revenue And Earnings By 2030
VRTX
Published: May 06, 2025 by: Seeking Alpha
Sentiment: Positive

Vertex Pharmaceuticals reported decent Q1 earnings, but the company missed estimates for both revenue and earnings. Vertex's diversification efforts are most visible in the progress of its pain management portfolio. The FDA approval of Journavx marks the beginning of a new era for the company. VRTX is not going to be the same company by 2030. I expect notable changes in its margin profile as the company diversifies into new markets.

Read More
image for news Vertex On Track To Significantly Improve Revenue And Earnings By 2030
Why Did Vertex Pharmaceuticals Stock Fall On Tuesday?
VRTX
Published: May 06, 2025 by: Benzinga
Sentiment: Negative

On Monday, Vertex Pharmaceuticals Incorporated VRTX reported lower-than-expected first-quarter 2025 earnings.

Read More
image for news Why Did Vertex Pharmaceuticals Stock Fall On Tuesday?
VRTX's Q1 Earnings Lag Estimates, 2025 Revenue View Tightened
VRTX
Published: May 06, 2025 by: Zacks Investment Research
Sentiment: Negative

Vertex reports weaker-than-expected first-quarter 2025 results. The company tightens its total revenue guidance for 2025.

Read More
image for news VRTX's Q1 Earnings Lag Estimates, 2025 Revenue View Tightened
Vertex Pharmaceuticals Stock Is Tumbling After Earnings. Here's Why.
VRTX
Published: May 06, 2025 by: Barrons
Sentiment: Negative

The company discloses narrower-than-expected access to its new painkiller.

Read More
image for news Vertex Pharmaceuticals Stock Is Tumbling After Earnings. Here's Why.
Top Stock Movers Now: Vertex, DoorDash, Constellation Energy, and More
CEG, DASH, VRTX
Published: May 06, 2025 by: Investopedia
Sentiment: Negative

U.S. equities were lower at midday as the market watched for any possible deals involving Trump administration tariffs and awaited tomorrow's statement from the Federal Reserve policymakers following their two-day meeting. The Dow Jones Industrial Average, S&P 500, and Nasdaq all fell.

Read More
image for news Top Stock Movers Now: Vertex, DoorDash, Constellation Energy, and More
2 Pharma Stocks Staging Big Post-Earnings Moves
NBIX, VRTX
Published: May 06, 2025 by: Schaeffers Research
Sentiment: Neutral

Biopharmaceutical giants Vertex Pharmaceuticals Inc (NASDAQ:VRTX) and Neurocrine Biosciences Inc (NASDAQ:NBIX) are fresh out of the earnings confessional, with very different results.

Read More
image for news 2 Pharma Stocks Staging Big Post-Earnings Moves
Why Vertex Pharmaceuticals Stock Is Sinking Today
VRTX
Published: May 06, 2025 by: The Motley Fool
Sentiment: Negative

Shares of Vertex Pharmaceuticals (VRTX -11.69%) were sinking 11.9% as of 10:18 a.m. ET on Tuesday.

Read More
image for news Why Vertex Pharmaceuticals Stock Is Sinking Today
Rising Costs Weigh on Vertex Q1 Earnings
VRTX
Published: May 06, 2025 by: The Motley Fool
Sentiment: Neutral

Here's our initial take on Vertex Pharmaceuticals' (VRTX -0.27%) first-quarter financial report.

Read More
image for news Rising Costs Weigh on Vertex Q1 Earnings
Vertex: Improved Outlook Despite First Quarter Miss (Rating Upgrade)
VRTX
Published: May 06, 2025 by: Seeking Alpha
Sentiment: Positive

Vertex Pharmaceuticals missed Q1 revenue and EPS estimates but this is not a cause for concern as the full-year outlook has improved. Alyftrek is off to a good start and early launch metrics of Journavx look promising. Casgevy's progress is slow but uptake should improve going forward.

Read More
image for news Vertex: Improved Outlook Despite First Quarter Miss (Rating Upgrade)
Final Trades: Berkshire Hathaway, Vertex Pharma, S&P Global and CME Group
BRK-A, BRK-B, CME, VRTX
Published: April 30, 2025 by: CNBC Television
Sentiment: Neutral

Final Trades are in! The Investment Committee reveals their top picks to close out the day—don't miss it!

Read More
image for news Final Trades: Berkshire Hathaway, Vertex Pharma, S&P Global and CME Group
What Analyst Projections for Key Metrics Reveal About Vertex (VRTX) Q1 Earnings
VRTX
Published: April 30, 2025 by: Zacks Investment Research
Sentiment: Positive

Looking beyond Wall Street's top -and-bottom-line estimate forecasts for Vertex (VRTX), delve into some of its key metrics to gain a deeper insight into the company's potential performance for the quarter ended March 2025.

Read More
image for news What Analyst Projections for Key Metrics Reveal About Vertex (VRTX) Q1 Earnings
Baron Health Care Fund Q1 2025 Top Contributors And Detractors
ACLX, BSX, DHR, GKOS, INSM, ISRG, LLY, RDNT, UNH, VRTX
Published: April 29, 2025 by: Seeking Alpha
Sentiment: Positive

Boston Scientific's shares rose due to strong market growth, innovative products like pulsed field ablation, and disciplined cost management, driving double-digit EPS growth. Vertex Pharmaceuticals saw increased investor confidence in its cystic fibrosis franchise and evolving pipeline, including promising non-opioid pain treatments and kidney disease drugs. UnitedHealth Group's shares gained as 2024 headwinds subsided, Medicare Advantage rates improved, and higher-margin Optum segments grew, insulating it from tariff impacts.

Read More
image for news Baron Health Care Fund Q1 2025 Top Contributors And Detractors
My 5 Top Stocks to Buy Right Now in This Highly Volatile Market
BRK-A, BRK-B, D, EPD, PFE, VRTX
Published: April 28, 2025 by: The Motley Fool
Sentiment: Positive

Getting dizzy from the stock market's gyrations? Join the club.

Read More
image for news My 5 Top Stocks to Buy Right Now in This Highly Volatile Market
Vertex Pharmaceuticals Incorporated (VRTX) Is a Trending Stock: Facts to Know Before Betting on It
VRTX
Published: April 23, 2025 by: Zacks Investment Research
Sentiment: Positive

Vertex (VRTX) has been one of the stocks most watched by Zacks.com users lately. So, it is worth exploring what lies ahead for the stock.

Read More
image for news Vertex Pharmaceuticals Incorporated (VRTX) Is a Trending Stock: Facts to Know Before Betting on It

About Vertex Pharmaceuticals Incorporated (VRTX)

  • IPO Date 1991-07-24
  • Website https://www.vrtx.com
  • Industry Biotechnology
  • CEO Reshma Kewalramani FASN,
  • Employees 6100

Vertex Pharmaceuticals Incorporated, a biotechnology company, engages in developing and commercializing therapies for treating cystic fibrosis. The company markets SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO to treat patients with cystic fibrosis who have specific mutations in their cystic fibrosis transmembrane conductance regulator gene; and TRIKAFTA for the treatment of patients with CF 6 years of age or older who have at least one F508del mutation. Its pipeline includes VX-864 for the treatment of AAT deficiency, which is in Phase 2 clinical trial; VX-147 for the treatment of APOL1-mediated focal segmental glomerulosclerosis, or FSGS, and other serious kidney diseases which is in Phase 2 clinical trial; VX- 880, treatment for Type 1 Diabetes which is in Phase 1/2 clinical trial; VX-548, a NaV1.8 inhibitor for treatments of acute, neuropathic, musculoskeletal pain which is in Phase 2 clinical trial; and CTX001 for the treatment severe SCD and TDT which is in Phase 3 clinical trial. The company sells its products primarily to specialty pharmacy and specialty distributors in the United States, as well as specialty distributors and retail chains, and hospitals and clinics internationally. It has collaborations with Affinia Therapeutics, Inc.; Arbor Biotechnologies, Inc.; CRISPR Therapeutics AG.; Kymera Therapeutics, Inc.; Mammoth Biosciences, Inc.; Moderna, Inc.; Obsidian Therapeutics, Inc.; and Skyhawk Therapeutics, Inc.; as well as Ribometrix, Inc.; Genomics plc; Merck KGaA; Darmstadt, Germany, and X-Chem, Inc. Vertex Pharmaceuticals Incorporated was founded in 1989 and is headquartered in Boston, Massachusetts.