Spyre Therapeutics, Inc. (SYRE)

US — Healthcare Sector
Peers:

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Key Metrics & Ratings

  • symbol SYRE
  • Rev/Share 0.0
  • Book/Share 1.3946
  • PB 12.168
  • Debt/Equity 0.0
  • CurrentRatio 8.0615
  • ROIC -0.4296

 

  • MktCap 1024200592.0
  • FreeCF/Share -0.4909
  • PFCF -6.0296
  • PE -28.1064
  • Debt/Assets 0.0
  • DivYield 0
  • ROE -0.491

 

  • Rating D+
  • Score 1
  • Recommendation Strong Sell
  • P/E Score 1
  • DCF Score 2
  • P/B Score 1
  • D/E Score 1

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Initiation SYRE Leerink Partners -- Outperform -- $45 April 8, 2025
Initiation SYRE Wolfe Research -- Outperform -- $27 March 18, 2025

News

Wall Street Analysts Predict a 244.05% Upside in Spyre Therapeutics (SYRE): Here's What You Should Know
SYRE
Published: May 30, 2025 by: Zacks Investment Research
Sentiment: Positive

The mean of analysts' price targets for Spyre Therapeutics (SYRE) points to a 244.1% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.

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image for news Wall Street Analysts Predict a 244.05% Upside in Spyre Therapeutics (SYRE): Here's What You Should Know
How Much Upside is Left in Spyre Therapeutics (SYRE)? Wall Street Analysts Think 258.34%
SYRE
Published: May 13, 2025 by: Zacks Investment Research
Sentiment: Positive

The average of price targets set by Wall Street analysts indicates a potential upside of 258.3% in Spyre Therapeutics (SYRE). While the effectiveness of this highly sought-after metric is questionable, the positive trend in earnings estimate revisions might translate into an upside in the stock.

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image for news How Much Upside is Left in Spyre Therapeutics (SYRE)? Wall Street Analysts Think 258.34%
Spyre Therapeutics to Participate in Upcoming March Investor Conferences
SYRE
Published: February 25, 2025 by: PRNewsWire
Sentiment: Neutral

WALTHAM, Mass. , Feb. 25, 2025 /PRNewswire/ -- Spyre Therapeutics, Inc. (NASDAQ: SYRE), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease ("IBD") and other immune-mediated diseases, today announced that management will participate in the following upcoming investor conferences: Event: TD Cowen 45th Annual Healthcare Conference Format: Fireside chat and 1x1 meetings Date/Time: Tuesday, March 4, 2025 at 3:10pm ET Location: Boston, MA Event: Jefferies Biotech on the Beach Summit Format: 1x1 meetings Date: Tuesday, March 11, 2025 Location: Miami, FL Live audio webcasts and replays of the …

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image for news Spyre Therapeutics to Participate in Upcoming March Investor Conferences
Spyre Therapeutics Announces Poster Presentation at the 20th Congress of the European Crohn's and Colitis Organisation
SYRE
Published: February 19, 2025 by: PRNewsWire
Sentiment: Neutral

WALTHAM, Mass. , Feb. 19, 2025 /PRNewswire/ -- Spyre Therapeutics, Inc. (NASDAQ: SYRE) (the "Company" or "Spyre"), a clinical-stage biotechnology company advancing best-in-class antibody engineering, dose optimization, and rational therapeutic combinations for the treatment of Inflammatory Bowel Disease ("IBD") and other immune-mediated diseases, today announced a poster presentation at the 20th Congress of the European Crohn's and Colitis Organisation (ECCO), held February 19-22, 2025, in Berlin, Germany, showing that combined inhibition of α4β7 integrin and TL1A cytokine is superior to either monotherapy in mouse models of colitis and coadministration demonstrates no drug-drug effects on exposure in non-human primates (NHPs).

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image for news Spyre Therapeutics Announces Poster Presentation at the 20th Congress of the European Crohn's and Colitis Organisation
Can Spyre Therapeutics (SYRE) Climb 158.85% to Reach the Level Wall Street Analysts Expect?
SYRE
Published: February 10, 2025 by: Zacks Investment Research
Sentiment: Positive

The consensus price target hints at a 158.9% upside potential for Spyre Therapeutics (SYRE). While empirical research shows that this sought-after metric is hardly effective, an upward trend in earnings estimate revisions could mean that the stock will witness an upside in the near term.

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image for news Can Spyre Therapeutics (SYRE) Climb 158.85% to Reach the Level Wall Street Analysts Expect?

About Spyre Therapeutics, Inc. (SYRE)

  • IPO Date 2016-04-07
  • Website https://www.spyre.com
  • Industry Biotechnology
  • CEO Dr. Cameron Turtle DPHIL, Ph.D.
  • Employees 73

Spyre Therapeutics, Inc., a preclinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is also developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004, a novel mechanism of action (MOA) mAb; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. Spyre Therapeutics, Inc. was incorporated in 2013 and is based in Waltham, Massachusetts.