Summit Therapeutics Inc. (SMMT)

US — Healthcare Sector
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Key Metrics & Ratings

  • symbol SMMT
  • Rev/Share 0.0
  • Book/Share 0.4665
  • PB 37.9938
  • Debt/Equity 0.0187
  • CurrentRatio 10.6302
  • ROIC -0.4826

 

  • MktCap 13075372683.0
  • FreeCF/Share -0.2351
  • PFCF -75.343
  • PE -54.339
  • Debt/Assets 0.0168
  • DivYield 0
  • ROE -0.705

 

  • Rating C
  • Score 2
  • Recommendation Sell
  • P/E Score 1
  • DCF Score 2
  • P/B Score 1
  • D/E Score 4

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Upgrade SMMT Citigroup Neutral Buy $23 $35 March 26, 2025
Initiation SMMT Cantor Fitzgerald -- Overweight -- -- March 21, 2025
Initiation SMMT Evercore ISI -- Outperform -- $30 March 12, 2025
Initiation SMMT Goldman -- Buy -- $42 Feb. 28, 2025
Initiation SMMT Truist -- Buy -- $35 Jan. 8, 2025
Initiation SMMT Wells Fargo -- Overweight -- $30 Dec. 11, 2024
Initiation SMMT Jefferies -- Buy -- $31 Dec. 6, 2024
Downgrade SMMT Citigroup Buy Neutral $19 $23 Sept. 27, 2024

News

Down 36.7% in 4 Weeks, Here's Why Summit Therapeutics (SMMT) Looks Ripe for a Turnaround
SMMT
Published: June 03, 2025 by: Zacks Investment Research
Sentiment: Positive

Summit Therapeutics (SMMT) is technically in oversold territory now, so the heavy selling pressure might have exhausted. This along with strong agreement among Wall Street analysts in raising earnings estimates could lead to a trend reversal for the stock.

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image for news Down 36.7% in 4 Weeks, Here's Why Summit Therapeutics (SMMT) Looks Ripe for a Turnaround
Summit Therapeutics: Market Overreaction Creates Opportunity
SMMT
Published: June 02, 2025 by: Seeking Alpha
Sentiment: Positive

Summit's ivonescimab showed a 48% reduction in disease progression risk in EGFR-mutant lung cancer — a best-in-class result in a tough-to-treat population. Overall survival data is trending positive but has not yet reached statistical significance; further follow-up may tip the balance. The recent stock sell-off reflects regulatory uncertainty rather than drug failure, creating a potential buying opportunity for long-term investors.

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image for news Summit Therapeutics: Market Overreaction Creates Opportunity
Summit Therapeutics Stock Nosedives on Mixed NSCLC Study Results
SMMT
Published: June 02, 2025 by: Zacks Investment Research
Sentiment: Negative

SMMT plunges 31% as its NSCLC drug shows strong PFS but misses statistical significance on survival data.

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image for news Summit Therapeutics Stock Nosedives on Mixed NSCLC Study Results
Is SMMT Stock A Buy After Its Recent Plunge?
SMMT
Published: June 02, 2025 by: Forbes
Sentiment: Negative

Summit Therapeutics (NASDAQ: SMMT) experienced a significant 30% decrease in its stock on Friday, May 30th, closing at $18. This sudden decline came even though the stock had doubled within the past year, driven by favorable updates regarding its lung cancer medication, ivonescimab.

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image for news Is SMMT Stock A Buy After Its Recent Plunge?
Is Beaten-Down Summit Therapeutics Stock a Bad-News Buy?
SMMT
Published: June 02, 2025 by: The Motley Fool
Sentiment: Negative

Shares of Summit Therapeutics (SMMT -30.39%) tanked more than 30% on Friday, May 30. Such dramatic price swings aren't unusual in the biotechnology industry; in this case, disappointing data from an important clinical trial drove the stock down.

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image for news Is Beaten-Down Summit Therapeutics Stock a Bad-News Buy?
Summit Therapeutics: Moving Stock To 'Hold' Rating After Phase 3 HARMONi Data Release
SMMT
Published: May 30, 2025 by: Seeking Alpha
Sentiment: Negative

PFS in Phase 3 HARMONi study, using ivonescimab + chemotherapy to treat patients with EGFR 2nd-line NSCLC, was met with statistical significance, but OS was not. OS data not being met in a statistically significant manner puts doubt on company's ability to file a BLA of ivonescimab for the treatment of patients with EGFR 2nd-line NSCLC. The global non-small cell lung cancer therapeutics market is expected to reach $37.49 billion by 2035.

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image for news Summit Therapeutics: Moving Stock To 'Hold' Rating After Phase 3 HARMONi Data Release
Summit Therapeutics Study Is a Win for China Biopharma Deals. Why the Stock Is Down.
SMMT
Published: May 30, 2025 by: Barrons
Sentiment: Positive

The trial was meant to answer the biggest question in biotech: What happens when U.S. companies test promising new Chinese cancer immunotherapies in western countries?

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image for news Summit Therapeutics Study Is a Win for China Biopharma Deals. Why the Stock Is Down.
Does Summit Therapeutics (SMMT) Have the Potential to Rally 44.6% as Wall Street Analysts Expect?
SMMT
Published: May 26, 2025 by: Zacks Investment Research
Sentiment: Positive

The mean of analysts' price targets for Summit Therapeutics (SMMT) points to a 44.6% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.

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image for news Does Summit Therapeutics (SMMT) Have the Potential to Rally 44.6% as Wall Street Analysts Expect?
Wall Street Analysts Predict a 33.4% Upside in Summit Therapeutics (SMMT): Here's What You Should Know
SMMT
Published: May 06, 2025 by: Zacks Investment Research
Sentiment: Positive

The consensus price target hints at a 33.4% upside potential for Summit Therapeutics (SMMT). While empirical research shows that this sought-after metric is hardly effective, an upward trend in earnings estimate revisions could mean that the stock will witness an upside in the near term.

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image for news Wall Street Analysts Predict a 33.4% Upside in Summit Therapeutics (SMMT): Here's What You Should Know
Summit Therapeutics Q1 Loss Narrower Than Expected, Sales Nil
SMMT
Published: May 02, 2025 by: Zacks Investment Research
Sentiment: Positive

SMMT's first-quarter earnings outpace estimates. The company also provides updates on its pipeline.

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image for news Summit Therapeutics Q1 Loss Narrower Than Expected, Sales Nil
Interim Overall Survival Analysis Requested from Chinese Health Authorities Shows a Clinically Meaningful, Positive Trend Favoring Ivonescimab Compared to Pembrolizumab in PD-L1 Positive Advanced NSCLC from HARMONi-2 Study Conducted by Akeso in China
SMMT
Published: April 25, 2025 by: Business Wire
Sentiment: Neutral

MIAMI--(BUSINESS WIRE)---- $SMMT--Summit Therapeutics Inc. (NASDAQ: SMMT) (“Summit,” “we,” or the “Company”) today noted that Akeso, Inc. (Akeso, HKEX Code: 9926.HK) announced that ivonescimab was approved by the Chinese Health Authorities, the National Medical Products Administration (NMPA), for a second indication based on the results of the Phase III clinical trial, HARMONi-2 or AK112-303. HARMONi-2 evaluated monotherapy ivonescimab against monotherapy pembrolizumab in patients with locally advanced o.

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image for news Interim Overall Survival Analysis Requested from Chinese Health Authorities Shows a Clinically Meaningful, Positive Trend Favoring Ivonescimab Compared to Pembrolizumab in PD-L1 Positive Advanced NSCLC from HARMONi-2 Study Conducted by Akeso in China
Summit Therapeutics: Multibillion Dollar NSCLC Potential Faces Growing Competition
SMMT
Published: April 14, 2025 by: Seeking Alpha
Sentiment: Neutral

Summit Therapeutics' ivonescimab shows promising results in China, outperforming Keytruda in PD-L1 positive advanced NSCLC, with potential $10 billion peak annual revenue. Fierce competition exists in the PD-1/VEGF bispecific antibody space, with major players like Merck and BioNTech entering the market. Summit's financial health shows a significant cash runway into late 2027, despite high R&D and G&A expenses and no revenue generation.

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image for news Summit Therapeutics: Multibillion Dollar NSCLC Potential Faces Growing Competition
3 Growth Stocks That Have Dwarfed Nvidia's Returns Over the Past 12 Months
APP, RKLB, SMMT
Published: April 03, 2025 by: The Motley Fool
Sentiment: Positive

Is the excitement surrounding chipmaker Nvidia fading? As of Monday, shares of the tech giant were down 19% since the start of 2025.

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image for news 3 Growth Stocks That Have Dwarfed Nvidia's Returns Over the Past 12 Months
Why Summit Therapeutics Stock Slipped Today
SMMT
Published: March 26, 2025 by: The Motley Fool
Sentiment: Negative

Summit Therapeutics (SMMT -2.25%) stock did better than a lot of other equities during an otherwise forgettable trading session on Wednesday. In contrast to other titles that fell notably, Summit more or less kept pace with the S&P 500 (^GSPC -1.12%), managing to dip by a relatively modest 2.25% in price.

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image for news Why Summit Therapeutics Stock Slipped Today
Analyst Initiates Coverage On 'Undervalued' Summit Therapeutics
SMMT
Published: March 24, 2025 by: Benzinga
Sentiment: Positive

On Friday, Cantor Fitzgerald initiated coverage on Summit Therapeutics Inc. SMMT, citing shares as 67% undervalued.

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image for news Analyst Initiates Coverage On 'Undervalued' Summit Therapeutics
This Unstoppable Biotech Stock Just Became an Even Better Buy
SMMT
Published: March 19, 2025 by: The Motley Fool
Sentiment: Positive

Last year, Summit Therapeutics (SMMT -1.24%) was one of the stars of the biotech industry. The company's shares soared following a significant clinical win.

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image for news This Unstoppable Biotech Stock Just Became an Even Better Buy
Akeso Highlights Collaboration Between Its Partner Summit Therapeutics and Pfizer to Explore Ivonescimab in Combination with Pfizer's ADCs
PFE, SMMT
Published: February 24, 2025 by: PRNewsWire
Sentiment: Neutral

HONG KONG , Feb. 24, 2025 /PRNewswire/ -- Akeso, Inc. (9926.HK) ("Akeso" or the "Company") today announced that its partner on ivonescimab, Summit Therapeutics Inc. (NASDAQ: SMMT) has entered into a clinical trial collaboration with Pfizer Inc. (NYSE: PFE) to evaluate ivonescimab, a novel, investigational PD-1 / VEGF bispecific antibody, in combination with several of Pfizer's antibody drug conjugates (ADCs) across multiple solid tumor settings. "Rapidly developing novel mechanisms that go beyond what is currently available to patients and physicians is what we believe will make the most significant impact for those facing the greatest challenges from cancer today," noted …

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image for news Akeso Highlights Collaboration Between Its Partner Summit Therapeutics and Pfizer to Explore Ivonescimab in Combination with Pfizer's ADCs
Summit Therapeutics: Mid-2025 NSCLC Data Could Further Entrench Ivonescimab Program
SMMT
Published: February 24, 2025 by: Seeking Alpha
Sentiment: Neutral

Summit Therapeutics: Mid-2025 NSCLC Data Could Further Entrench Ivonescimab Program

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image for news Summit Therapeutics: Mid-2025 NSCLC Data Could Further Entrench Ivonescimab Program
Pfizer: What The Summit Therapeutics Deal Brings
PFE, SMMT
Published: February 24, 2025 by: Seeking Alpha
Sentiment: Neutral

Pfizer: What The Summit Therapeutics Deal Brings

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image for news Pfizer: What The Summit Therapeutics Deal Brings
3 Stocks That Could Trounce the Market in 2025
LLY, SMMT, VRTX
Published: February 17, 2025 by: The Motley Fool
Sentiment: Positive

If you're content with market-level returns, investing in an exchange-traded fund (ETF) is the way to go. But if not, you'll need to find stocks that hold the potential to pack more punch.

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image for news 3 Stocks That Could Trounce the Market in 2025
Summit Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)
SMMT
Published: February 14, 2025 by: Business Wire
Sentiment: Neutral

MIAMI--(BUSINESS WIRE)---- $SMMT--Summit Therapeutics Inc. (NASDAQ: SMMT) ("Summit," "we," or the "Company") today announced the grant of inducement awards of options to purchase a collective total of up to 116,725 shares of common stock. Awards were made to nine new employees of the Company. The awards were granted as an inducement material to the new employees becoming employees of the Company in accordance with Nasdaq Listing Rule 5635(c)(4) and have been approved by the Company's Compensation Committ.

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image for news Summit Therapeutics Reports Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)

About Summit Therapeutics Inc. (SMMT)

  • IPO Date 2015-03-05
  • Website https://www.summittxinc.com
  • Industry Biotechnology
  • CEO Mr. Robert W. Duggan
  • Employees 159

Summit Therapeutics Inc., a biopharmaceutical company, discovers, develops, and commercializes medicines to treat infectious diseases in the United States and Latin America. It conducts clinical programs focusing on Clostridioides difficile infection (CDI). The company's lead product candidate is ridinilazole, an orally administered small molecule antibiotic that is in Phase III clinical trials for the treatment of CDI. It also offers SMT-738, for combating multidrug resistant infections primarily carbapenem-resistant Enterobacteriaceae infections; and DDS-04 series for the potential treatment of infections caused by the Enterobacteriaceae. The company was founded in 2003 and is based in Cambridge, Massachusetts.