Septerna, Inc. (SEPN)

US — Healthcare Sector
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Key Metrics & Ratings

  • symbol SEPN
  • Rev/Share 0.0165
  • Book/Share 9.1099
  • PB 1.1548
  • Debt/Equity 0.0625
  • CurrentRatio 32.193
  • ROIC -0.0927

 

  • MktCap 468753316.0
  • FreeCF/Share -1.6551
  • PFCF -6.4457
  • PE -16.6428
  • Debt/Assets 0.0577
  • DivYield 0
  • ROE -0.167

 

  • Rating B-
  • Score 3
  • Recommendation Neutral
  • P/E Score 1
  • DCF Score 5
  • P/B Score 4
  • D/E Score 3

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Downgrade SEPN Wells Fargo Overweight Equal Weight -- $14 Feb. 18, 2025

News

Analysts Think These Stocks Could More Than Double in Value
NTLA, NVAX, SEPN
Published: May 23, 2025 by: MarketBeat
Sentiment: Negative

Persistent volatility has plagued the S&P 500 for much of 2025, prompting widespread caution among many investors amid the uncertainties of trade battles, tariffs, domestic policy, and more. Investors might remember that many of the biggest rallies take place during these volatile periods, and there may be potential to win big gains for those with at least a moderate tolerance for risk.

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image for news Analysts Think These Stocks Could More Than Double in Value
Does Septerna, Inc. (SEPN) Have the Potential to Rally 151.27% as Wall Street Analysts Expect?
SEPN
Published: May 21, 2025 by: Zacks Investment Research
Sentiment: Positive

The mean of analysts' price targets for Septerna, Inc. (SEPN) points to a 151.3% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.

Read More
image for news Does Septerna, Inc. (SEPN) Have the Potential to Rally 151.27% as Wall Street Analysts Expect?
Septerna: Deal With Novo Nordisk Is A Game Changer While It Still Trades Well Below Net Cash
NVO, SEPN
Published: May 16, 2025 by: Seeking Alpha
Sentiment: Positive

Septerna's partnership with Novo Nordisk validates its GPCR drug discovery platform and injects $195 million in upfront cash, with potential for more than $2 billion in milestone payments. The stock trades below net cash even after the Novo deal, offering investors a rare opportunity to buy the pipeline and partnership essentially for free. NVO will cover R&D costs for four programs, extending SEPN's cash runway and reducing burn rate, while de-risking early-stage development.

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image for news Septerna: Deal With Novo Nordisk Is A Game Changer While It Still Trades Well Below Net Cash
ETFs to Capitalize on the Novo Nordisk-Septerna Deal
NVO, SEPN
Published: May 15, 2025 by: Zacks Investment Research
Sentiment: Positive

Novo Nordisk announces a $2.2 billion deal with Septerna to tap the growing obesity treatment market.

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image for news ETFs to Capitalize on the Novo Nordisk-Septerna Deal
Septerna Stock Surges on Oral Obesity Drug Deal With Novo Nordisk
NVO, SEPN
Published: May 15, 2025 by: Zacks Investment Research
Sentiment: Positive

SEPN is entitled to receive around $2.2 billion from NVO under the new collaboration deal, which aims to develop oral pills for obesity and other diseases.

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image for news Septerna Stock Surges on Oral Obesity Drug Deal With Novo Nordisk
Septerna stock pops on partnership with Novo Nordisk to develop obesity therapies
NVO, SEPN
Published: May 14, 2025 by: Proactive Investors
Sentiment: Positive

Septerna (NASDAQ:SEPN) shares surged almost 50% after the announcement of an exclusive global collaboration and license deal with Novo Nordisk (NYSE:NVO) to develop oral small molecule medicines targeting obesity and other cardiometabolic diseases. The partnership brings together Septerna's expertise in G protein-coupled receptor (GPCR) drug discovery with Nono Nordisk's established obesity and metabolic disease therapies, which include the injectables Wegovy and Ozempic.

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image for news Septerna stock pops on partnership with Novo Nordisk to develop obesity therapies
Wall Street Analysts Predict a 207.31% Upside in Septerna, Inc. (SEPN): Here's What You Should Know
SEPN
Published: April 16, 2025 by: Zacks Investment Research
Sentiment: Positive

The mean of analysts' price targets for Septerna, Inc. (SEPN) points to a 207.3% upside in the stock. While this highly sought-after metric has not proven reasonably effective, strong agreement among analysts in raising earnings estimates does indicate an upside in the stock.

Read More
image for news Wall Street Analysts Predict a 207.31% Upside in Septerna, Inc. (SEPN): Here's What You Should Know
Biotech Stocks Q1 2025 Recap: Winners And Underperformers
CMRX, CRVO, CVS, GERN, LLY, NVO, SEPN
Published: March 31, 2025 by: Seeking Alpha
Sentiment: Positive

Investing in biotech can be highly rewarding but is fraught with risks; understanding past catalysts can help investors make informed decisions and minimize downside risk. CervoMed Inc. surged over 300% in Q1 2025 due to positive Phase 2b trial results for its lead drug candidate, neflamapimod despite earlier setbacks. Chimerix Inc. gained over 144% after announcing an acquisition by Jazz Pharmaceuticals and positive FDA feedback on its lead drug candidate, dordaviprone.

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image for news Biotech Stocks Q1 2025 Recap: Winners And Underperformers
Septerna Provides Corporate Overview and Reports Fourth Quarter and Full Year 2024 Financial Results
SEPN
Published: March 27, 2025 by: GlobeNewsWire
Sentiment: Neutral

Preclinical Work Advancing with Plans to Select a Next-Generation Oral Small Molecule PTH1R Agonist to Accelerate Toward the Clinic Later This Year Phase 1 Trial for SEP-631, MRGPRX2 NAM Program for Mast Cell Diseases, Expected to Initiate in 2025 Well-Capitalized with $420.8M Balance Sheet as of YE 2024 to Support Operating Runway into Early 2028 SOUTH SAN FRANCISCO, Calif., March 27, 2025 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today provided a corporate overview complete with upcoming milestones and reported fourth quarter and full year 2024 …

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image for news Septerna Provides Corporate Overview and Reports Fourth Quarter and Full Year 2024 Financial Results
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 19, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK CITY, NY / ACCESS Newswire / March 19, 2025 / Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ:SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 17, 2025 by: PRNewsWire
Sentiment: Neutral

NEW YORK , March 17, 2025 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ: SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 13, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK CITY, NY / ACCESS Newswire / March 13, 2025 / Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ:SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 07, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / March 7, 2025 / Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ:SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Shareholders to Reach Out
SEPN
Published: March 06, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / March 6, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Shareholders to Reach Out
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 05, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / March 5, 2025 / Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ:SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
Bronstein, Gewirtz & Grossman, LLC Announces an Investigation Against Septerna, Inc. (SEPN) and Encourages Shareholders to Learn More About the Investigation
SEPN
Published: March 05, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / March 5, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Announces an Investigation Against Septerna, Inc. (SEPN) and Encourages Shareholders to Learn More About the Investigation
Septerna, Inc. (SEPN) Investigation: Bronstein, Gewirtz & Grossman, LLC Encourages Investors to Contact the Firm to Learn More About the Investigation
SEPN
Published: March 04, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / March 4, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Septerna, Inc. (SEPN) Investigation: Bronstein, Gewirtz & Grossman, LLC Encourages Investors to Contact the Firm to Learn More About the Investigation
INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
SEPN
Published: March 03, 2025 by: PRNewsWire
Sentiment: Neutral

NEW YORK , March 3, 2025 /PRNewswire/ -- Pomerantz LLP is investigating claims on behalf of investors of Septerna, Inc ("Septerna" or the "Company") (NASDAQ: SEPN). Such investors are advised to contact Danielle Peyton at [email protected] or 646-581-9980, ext.

Read More
image for news INVESTOR ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Septerna, Inc. - SEPN
Bronstein, Gewirtz & Grossman, LLC Is Investigating Septerna, Inc. (SEPN) And Encourages Investors to Connect
SEPN
Published: February 28, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / February 28, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Is Investigating Septerna, Inc. (SEPN) And Encourages Investors to Connect
Septerna to Present at TD Cowen 45th Annual Health Care Conference
SEPN
Published: February 26, 2025 by: GlobeNewsWire
Sentiment: Neutral

SOUTH SAN FRANCISCO, Calif., Feb. 26, 2025 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that Jeffrey Finer, M.D.

Read More
image for news Septerna to Present at TD Cowen 45th Annual Health Care Conference
Septerna, Inc. (SEPN) Investigation: Bronstein, Gewirtz & Grossman, LLC Encourages Stockholders to Contact the Firm to Learn More About the Investigation
SEPN
Published: February 24, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / February 24, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Septerna, Inc. (SEPN) Investigation: Bronstein, Gewirtz & Grossman, LLC Encourages Stockholders to Contact the Firm to Learn More About the Investigation
Bronstein, Gewirtz & Grossman, LLC Encourages Septerna, Inc. (SEPN) Investors to Inquire about Securities Investigation
SEPN
Published: February 21, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / February 21, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Encourages Septerna, Inc. (SEPN) Investors to Inquire about Securities Investigation
Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Investors to Reach Out
SEPN
Published: February 20, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / February 20, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Investors to Reach Out
Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Stockholders to Reach Out
SEPN
Published: February 19, 2025 by: Accesswire
Sentiment: Neutral

NEW YORK, NY / ACCESS Newswire / February 19, 2025 / Bronstein, Gewirtz & Grossman, LLC is investigating potential claims on behalf of purchasers of Septerna, Inc. ("Septerna" or "the Company") (NASDAQ:SEPN). Investors who purchased Septerna securities are encouraged to obtain additional information and assist the investigation by visiting the firm's site: bgandg.com/SEPN.

Read More
image for news Bronstein, Gewirtz & Grossman, LLC Initiates an Investigation into Allegations Against Septerna, Inc. (SEPN) And Encourages Stockholders to Reach Out
Septerna halts Phase 1 hypoparathyroidism trial, shares plummet
SEPN
Published: February 18, 2025 by: Proactive Investors
Sentiment: Negative

Septerna (NASDAQ:SEPN) shares tumbled more than 60% after the clinical-stage biotechnology firm announced it is halting its Phase 1 clinical trial of SEP-786 targeting hypoparathyroidism. The company said it chose to discontinue the trial due to the occurrence of elevated bilirubin levels in trial participants.

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image for news Septerna halts Phase 1 hypoparathyroidism trial, shares plummet
Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist
SEPN
Published: February 18, 2025 by: GlobeNewsWire
Sentiment: Neutral

Trial decision follows unanticipated events of elevated unconjugated bilirubin levels Company advancing multiple next-generation PTH1R agonists with distinct and unrelated chemical structures relative to SEP-786 SOUTH SAN FRANCISCO, Calif., Feb. 18, 2025 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of GPCR drug discovery, today announced its decision to discontinue the Phase 1 single- and multiple-ascending dose (SAD/MAD) clinical trial of SEP-786 in healthy volunteers.

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image for news Septerna Announces Discontinuation of SEP-786 Phase 1 Clinical Trial and Plans to Advance Next-Generation Oral Small Molecule PTH1R Agonist

About Septerna, Inc. (SEPN)

  • IPO Date 2024-10-25
  • Website https://septerna.com
  • Industry Biotechnology
  • CEO Dr. Jeffrey T. Finer M.D., Ph.D.
  • Employees 75

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products candidates for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. The company develops SEP-786, an oral small molecule PTH1R agonist for hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 NAM for chronic spontaneous urticaria and other mast cell diseases; TSHR Program, an oral small molecule TSHR NAM for Graves' disease and thyroid eye disease. It also develops oral small molecule single- and multi-incretin receptor agonists for metabolic disorders including obesity and type 2 diabetes. Septerna, Inc. was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. The company was incorporated in 2019 and is headquartered in South San Francisco, California.