SEPN

Septerna, Inc. Common Stock
NASDAQHEALTHCAREBIOTECHNOLOGY

Key Statistics

Market Cap
$1.72B
P/E Ratio
EPS
$-0.53
Beta
52W High
$51.10
52W Low
$13.67
50-Day MA
$37.51
200-Day MA
$29.70
Dividend Yield
Profit Margin
-24.50%
Forward P/E
107.53
PEG Ratio

About Septerna, Inc. Common Stock

Septerna, Inc. is a cutting-edge biotechnology firm dedicated to transforming disease treatment through its advanced selective protein modulation platform. The company combines proprietary technologies with a distinguished scientific team to create a diverse pipeline of innovative therapeutics aimed at addressing significant unmet medical needs across various therapeutic areas. With a strong emphasis on research and development, Septerna is poised for substantial growth, presenting institutional investors with an attractive opportunity in the rapidly evolving biopharmaceutical landscape.

Official WebsiteUSAFY End: December

Fundamentals

Revenue (TTM)$98.88M
Gross Profit (TTM)$98.88M
EBITDA$-54.40M
Operating Margin-62.90%
Return on Equity-6.34%
Return on Assets-7.13%
Revenue/Share (TTM)$2.21
Book Value$8.43
Price-to-Book4.44
Price-to-Sales (TTM)17.35
EV/Revenue13.81
EV/EBITDA
Quarterly Earnings Growth (YoY)0.00%
Quarterly Revenue Growth (YoY)22376.00%
Shares Outstanding$46.68M
Float$26.41M
% Insiders3.07%
% Institutions98.94%

Historical Volatility

HV 10-Day
28.85%
HV 20-Day
86.76%
HV 30-Day
79.21%
HV 60-Day
75.29%
HV Rank
83.3%

Volatility is currently contracting

Analyst Ratings

Consensus ($54.22 target)
1
Strong Buy
9
Buy

Latest News

Septerna to Participate in Upcoming Investor Conferences

SOUTH SAN FRANCISCO, Calif., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that management will participate in the following investor conferences in September:

GlobeNewsWire9/1/2026Neutral
Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

SOUTH SAN FRANCISCO, Calif., Aug. 25, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced the appointment of Rajiv Patni, M.D., as Chief Medical Officer. Dr. Patni is a physician-scientist and accomplished biopharmaceutical executive with more than 25 years of experience leading research, development, regulatory, and medical affairs organizations.

GlobeNewsWire8/25/2026Neutral
Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

15,000 shares were exercised and sold for a total of ~$533,000 on June 22, 2026, at a weighted average price of around $35.51 per share. This transaction impacted 13.46% of Long's direct Common Stock holdings, reducing his position to 96,412 shares.

The Motley Fool6/30/2026Negative

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Data last updated: 9/7/2026