SEPN

Septerna, Inc. Common Stock
NASDAQHEALTHCAREBIOTECHNOLOGY

Key Statistics

Market Cap
$1.76B
P/E Ratio
—
EPS
$-0.53
Beta
—
52W High
$51.10
52W Low
$17.33
50-Day MA
$38.42
200-Day MA
$30.50
Dividend Yield
—
Profit Margin
-24.50%
Forward P/E
107.53
PEG Ratio
—

About Septerna, Inc. Common Stock

Septerna, Inc. is a cutting-edge biotechnology firm dedicated to transforming disease treatment through its advanced selective protein modulation platform. The company combines proprietary technologies with a distinguished scientific team to create a diverse pipeline of innovative therapeutics aimed at addressing significant unmet medical needs across various therapeutic areas. With a strong emphasis on research and development, Septerna is poised for substantial growth, presenting institutional investors with an attractive opportunity in the rapidly evolving biopharmaceutical landscape.

Official WebsiteUSAFY End: December

Fundamentals

Revenue (TTM)$98.88M
Gross Profit (TTM)$98.88M
EBITDA$-54.40M
Operating Margin-62.90%
Return on Equity-6.34%
Return on Assets-7.13%
Revenue/Share (TTM)$2.21
Book Value$8.47
Price-to-Book4.64
Price-to-Sales (TTM)17.83
EV/Revenue14.61
EV/EBITDA—
Quarterly Earnings Growth (YoY)0.00%
Quarterly Revenue Growth (YoY)22376.00%
Shares Outstanding$46.68M
Float$26.41M
% Insiders3.07%
% Institutions99.03%

Historical Volatility

HV 10-Day
44.33%
HV 20-Day
36.87%
HV 30-Day
38.29%
HV 60-Day
67.13%
HV Rank
0.0%

Volatility is currently expanding

Analyst Ratings

Consensus ($54.22 target)
1
Strong Buy
9
Buy

Latest News

Septerna, Inc. Announces Inducement Grant Under Nasdaq Listing Rule 5635(c)(4)

SOUTH SAN FRANCISCO, Calif., Sept. 10, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), today announced that the Company granted a non-qualified stock option to purchase up to 275,000 shares of the Company's common stock to Rajiv Patni, M.D., the Company's newly appointed Chief Medical Officer, under the Company's 2026 Inducement Plan (the “Inducement Plan”). The inducement grant was effective as of September 8, 2026. The award was granted as an inducement material to Dr. Patni's employment with the Company in accordance with Nasdaq Listing Rule 5635(c)(4).

GlobeNewsWire9/10/2026Neutral
Septerna to Participate in Upcoming Investor Conferences

SOUTH SAN FRANCISCO, Calif., Sept. 01, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced that management will participate in the following investor conferences in September:

GlobeNewsWire9/1/2026Neutral
Septerna Appoints Industry Veteran Rajiv Patni, M.D., as Chief Medical Officer

SOUTH SAN FRANCISCO, Calif., Aug. 25, 2026 (GLOBE NEWSWIRE) -- Septerna, Inc. (Nasdaq: SEPN), a clinical-stage biotechnology company pioneering a new era of G protein-coupled receptor (GPCR) drug discovery, today announced the appointment of Rajiv Patni, M.D., as Chief Medical Officer. Dr. Patni is a physician-scientist and accomplished biopharmaceutical executive with more than 25 years of experience leading research, development, regulatory, and medical affairs organizations.

GlobeNewsWire8/25/2026Neutral
Is Septerna a Stock to Sell After an Insider Let Go of 15,000 Shares?

15,000 shares were exercised and sold for a total of ~$533,000 on June 22, 2026, at a weighted average price of around $35.51 per share. This transaction impacted 13.46% of Long's direct Common Stock holdings, reducing his position to 96,412 shares.

The Motley Fool6/30/2026Negative

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Data last updated: 9/26/2026