Ionis Pharmaceuticals, Inc. (IONS)

US — Healthcare Sector
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Key Metrics & Ratings

  • symbol IONS
  • Rev/Share 4.5197
  • Book/Share 2.997
  • PB 11.1812
  • Debt/Equity 2.9641
  • CurrentRatio 9.6644
  • ROIC -0.1816

 

  • MktCap 5333418090.0
  • FreeCF/Share -3.5857
  • PFCF -9.3704
  • PE -11.6132
  • Debt/Assets 0.5013
  • DivYield 0
  • ROE -0.9206

 

  • Rating D+
  • Score 1
  • Recommendation Strong Sell
  • P/E Score 1
  • DCF Score 1
  • P/B Score 1
  • D/E Score 1

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Initiation IONS H.C. Wainwright -- Buy -- $45 April 7, 2025
Initiation IONS Redburn Atlantic -- Neutral -- $39 March 31, 2025

News

Why Is Ionis Pharmaceuticals (IONS) Up 5.5% Since Last Earnings Report?
IONS
Published: May 30, 2025 by: Zacks Investment Research
Sentiment: Positive

Ionis Pharmaceuticals (IONS) reported earnings 30 days ago. What's next for the stock?

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image for news Why Is Ionis Pharmaceuticals (IONS) Up 5.5% Since Last Earnings Report?
Ionis' Tryngolza Cuts Triglyceride Levels in Late-Stage Study
IONS
Published: May 20, 2025 by: Zacks Investment Research
Sentiment: Neutral

Late-stage data shows that treatment with an 80mg dose of IONS' Tryngolza achieved a 61% placebo-adjusted reduction in triglyceride levels in six months.

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image for news Ionis' Tryngolza Cuts Triglyceride Levels in Late-Stage Study
Ionis announces positive topline results from Essence study of olezarsen in people with moderately elevated triglycerides
IONS
Published: May 19, 2025 by: Business Wire
Sentiment: Neutral

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced positive topline results from the Essence study of olezarsen in people with moderate hypertriglyceridemia (fasting triglycerides ≥150 mg/dL to

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image for news Ionis announces positive topline results from Essence study of olezarsen in people with moderately elevated triglycerides
Ionis to host 2025 virtual Annual Meeting of Stockholders
IONS
Published: May 06, 2025 by: Business Wire
Sentiment: Neutral

CARLSBAD, Calif.--(BUSINESS WIRE)--Ionis Pharmaceuticals, Inc. (Nasdaq: IONS) today announced that management will conduct its 2025 virtual Annual Meeting of Stockholders followed by a general corporate update on Thursday, June 5, 2025. The agenda for the event is as follows: 5:00 p.m. – 5:15 p.m. ET (2:00 p.m. – 2:15 p.m. PT) – Virtual Annual Meeting of Stockholders All stockholders of record at the close of business on April 7, 2025, are invited to participate in the virtual Annual Meeting we.

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image for news Ionis to host 2025 virtual Annual Meeting of Stockholders
Ionis Q1 Earnings and Sales Top Estimates, Stock Gains on Raised '25 View
IONS
Published: May 01, 2025 by: Zacks Investment Research
Sentiment: Positive

IONS reports better-than-expected first-quarter results. The company raises its sales guidance for 2025 by more than 20% on the back of two new licensing deals.

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image for news Ionis Q1 Earnings and Sales Top Estimates, Stock Gains on Raised '25 View
Ionis Pharmaceuticals, Inc. (IONS) Q1 2025 Earnings Call Transcript
IONS
Published: April 30, 2025 by: Seeking Alpha
Sentiment: Neutral

Ionis Pharmaceuticals, Inc. (NASDAQ:IONS ) Q1 2025 Earnings Conference Call April 30, 2025 11:30 AM ET Company Participants Wade Walke - SVP, IR Brett Monia - Founder, CEO & Director Kyle Jenne - EVP & Chief Global Product Strategy Officer Beth Hougen - EVP, Finance & CFO Jonathan Birchall - SVP & Chief Commercial Officer Eugene Schneider - EVP, Chief Clinical Development & Operations Officer Conference Call Participants Jay Olson - Oppenheimer Gary Nachman - Raymond James Debjit Chattopadhyay - Guggenheim Jessica Fye - JPMorgan Chi Meng Fong - Bank of America Merrill Lynch Yaron Werber - TD Cowen David …

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image for news Ionis Pharmaceuticals, Inc. (IONS) Q1 2025 Earnings Call Transcript
Ionis Pharmaceuticals (IONS) Reports Q1 Earnings: What Key Metrics Have to Say
IONS
Published: April 30, 2025 by: Zacks Investment Research
Sentiment: Positive

Although the revenue and EPS for Ionis Pharmaceuticals (IONS) give a sense of how its business performed in the quarter ended March 2025, it might be worth considering how some key metrics compare with Wall Street estimates and the year-ago numbers.

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image for news Ionis Pharmaceuticals (IONS) Reports Q1 Earnings: What Key Metrics Have to Say
Ionis Pharmaceuticals (IONS) Reports Q1 Loss, Tops Revenue Estimates
IONS
Published: April 30, 2025 by: Zacks Investment Research
Sentiment: Negative

Ionis Pharmaceuticals (IONS) came out with a quarterly loss of $0.75 per share versus the Zacks Consensus Estimate of a loss of $1.11. This compares to loss of $0.98 per share a year ago.

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image for news Ionis Pharmaceuticals (IONS) Reports Q1 Loss, Tops Revenue Estimates
Ionis: Potentially A Great Time To Buy Ahead Of Q1 Earnings (Upgrade)
IONS
Published: April 22, 2025 by: Seeking Alpha
Sentiment: Positive

Ionis will announce its Q1 earnings on April 30th - in my view, the company is in a strong position and its current valuation of $4.5bn is far too low. The company recently secured approval for olezarsen in FCS, and looks odds on for a follow-up approval in SHTG - a "blockbuster" indication. Management believes >$3bn revenues and >$2bn royalties + milestones may be achieveable long-term, with multiple new product launches for wholly-owned and partnered assets.

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image for news Ionis: Potentially A Great Time To Buy Ahead Of Q1 Earnings (Upgrade)
Ionis Pharmaceuticals (IONS) Surges 8.9%: Is This an Indication of Further Gains?
IONS
Published: April 10, 2025 by: Zacks Investment Research
Sentiment: Positive

Ionis Pharmaceuticals (IONS) witnessed a jump in share price last session on above-average trading volume. The latest trend in earnings estimate revisions for the stock doesn't suggest further strength down the road.

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image for news Ionis Pharmaceuticals (IONS) Surges 8.9%: Is This an Indication of Further Gains?
Why Is Ionis Pharmaceuticals (IONS) Up 0.1% Since Last Earnings Report?
IONS
Published: March 21, 2025 by: Zacks Investment Research
Sentiment: Positive

Ionis Pharmaceuticals (IONS) reported earnings 30 days ago. What's next for the stock?

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image for news Why Is Ionis Pharmaceuticals (IONS) Up 0.1% Since Last Earnings Report?
Ionis Pharmaceuticals Reports Strong Q4 Earnings After Recent FDA Approval
IONS
Published: February 19, 2025 by: Seeking Alpha
Sentiment: Positive

Ionis Pharmaceuticals' Q4 earnings beat expectations, but guidance for 2025 was slightly below consensus, leading to a HOLD rating pending further catalysts. TRYNGOLZA's approval for FCS is promising, but expansion into the larger sHTG market by 2025 is crucial for the company to reach profitability and satisfy analyst's estimates. Ionis has a strong cash position and a robust pipeline of over 40 RNA-targeted therapeutics, making it a compelling watch-list candidate.

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image for news Ionis Pharmaceuticals Reports Strong Q4 Earnings After Recent FDA Approval
Ionis Pharma Beats Expectations for Q4
IONS
Published: February 19, 2025 by: The Motley Fool
Sentiment: Positive

Ionis Pharmaceuticals (IONS 0.44%), a leader in RNA-targeted drug discovery and development, announced its earnings results for the fourth quarter on Feb. 19. The report revealed that Ionis outperformed analysts' top-line expectations with revenue of $227 million compared to the anticipated $135 million.

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image for news Ionis Pharma Beats Expectations for Q4
Ionis Pharmaceuticals (IONS) Reports Q4 Earnings: What Key Metrics Have to Say
IONS
Published: February 19, 2025 by: Zacks Investment Research
Sentiment: Neutral

While the top- and bottom-line numbers for Ionis Pharmaceuticals (IONS) give a sense of how the business performed in the quarter ended December 2024, it could be worth looking at how some of its key metrics compare to Wall Street estimates and year-ago values.

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image for news Ionis Pharmaceuticals (IONS) Reports Q4 Earnings: What Key Metrics Have to Say

About Ionis Pharmaceuticals, Inc. (IONS)

  • IPO Date 1991-05-17
  • Website https://www.ionispharma.com
  • Industry Biotechnology
  • CEO Dr. Brett P. Monia Ph.D.
  • Employees 1069

Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It also develops medicines for various indications that are in phase 3 study, including Eplontersen as a monthly self-administered subcutaneous injection to treat all types of TTR amyloidosis; Olezarsen for patients with severe hypertriglyceridemia (SHTG); Donidalorsen for patients with hereditary angioedema; ION363 for patients with amyotrophic lateral sclerosis; Pelacarsen for patients with established cardiovascular disease and elevated lipoprotein(a); and Tofersen to inhibit the production of superoxide dismutase 1. In addition, the company develops medicines for metabolic diseases, infectious diseases, renal diseases, ophthalmic diseases, and cancer. It has a strategic collaboration with Biogen Inc.; and collaboration and license agreement with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.