Denali Therapeutics Inc. (DNLI)

US — Healthcare Sector
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Key Metrics & Ratings

  • symbol DNLI
  • Rev/Share 0.0
  • Book/Share 6.5569
  • PB 2.0192
  • Debt/Equity 0.0433
  • CurrentRatio 9.5632
  • ROIC -0.4337

 

  • MktCap 1923454240.0
  • FreeCF/Share -2.2449
  • PFCF -5.004
  • PE -4.994
  • Debt/Assets 0.0383
  • DivYield 0
  • ROE -0.359

 

  • Rating C+
  • Score 2
  • Recommendation Sell
  • P/E Score 1
  • DCF Score 3
  • P/B Score 3
  • D/E Score 3

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Upgrade DNLI Cantor Fitzgerald Neutral Overweight -- -- April 10, 2025
Resumed DNLI Morgan Stanley -- Overweight $41 $33 March 7, 2025
Initiation DNLI Deutsche Bank -- Buy -- $31 Feb. 11, 2025
Initiation DNLI Robert W. Baird -- Outperform -- $31 Jan. 7, 2025
Initiation DNLI William Blair -- Outperform -- -- Jan. 3, 2025
Upgrade DNLI Stifel Hold Buy -- $37 Dec. 16, 2024
Resumed DNLI Raymond James -- Market Perform -- -- Oct. 10, 2024
Downgrade DNLI Cantor Fitzgerald Overweight Neutral -- -- Oct. 7, 2024

News

Denali Q1 Loss Wider Than Expected, Hunter Syndrome Drug in Focus
DNLI
Published: May 07, 2025 by: Zacks Investment Research
Sentiment: Negative

DNLI reports a wider-than-expected loss for the first quarter of 2025. Denali submits a BLA for tividenofusp alfa under the FDA?

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image for news Denali Q1 Loss Wider Than Expected, Hunter Syndrome Drug in Focus
5 Drug/Biotech Stocks Likely to Outperform Q1 Earnings Estimates
ACAD, DNLI, NVO, PCRX, RARE
Published: May 05, 2025 by: Zacks Investment Research
Sentiment: Positive

Let us look at some drug/biotech stocks, NVO, PCRX, RARE, ACAD and DNLI, which are poised to beat on first-quarter 2025 earnings.

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image for news 5 Drug/Biotech Stocks Likely to Outperform Q1 Earnings Estimates
DNLI Begins Rolling BLA Submission for Hunter Syndrome Drug, Stock Up
DNLI
Published: April 03, 2025 by: Zacks Investment Research
Sentiment: Positive

Denali stock up as it begins rolling BLA submission with the FDA for accelerated approval of tividenofusp alfa for the treatment of Hunter syndrome.

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image for news DNLI Begins Rolling BLA Submission for Hunter Syndrome Drug, Stock Up
Denali Therapeutics: Vast Pipeline, First Approval Up Ahead
DNLI
Published: March 20, 2025 by: Seeking Alpha
Sentiment: Positive

Denali Therapeutics' stock has significantly dropped from $100 to $15 since 2021, but the company is now heavily derisked with promising product candidates nearing key milestones. Lead asset DNL310 shows strong biomarker data for Hunter syndrome, with plans for a BLA submission and accelerated approval by Q2 2025. The Biogen partnership for Parkinson's Disease asset DNL151 includes substantial milestone payments and profit-sharing, highlighting its potential impact.

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image for news Denali Therapeutics: Vast Pipeline, First Approval Up Ahead
Why You Shouldn't Bet Against Denali (DNLI) Stock
DNLI
Published: March 20, 2025 by: Zacks Investment Research
Sentiment: Positive

Denali (DNLI) has seen solid earnings estimate revision activity over the past month, and belongs to a strong industry as well.

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image for news Why You Shouldn't Bet Against Denali (DNLI) Stock
Denali Q4 Earnings Beat Estimates, Hunter Syndrome Drug in Focus
DNLI
Published: February 28, 2025 by: Zacks Investment Research
Sentiment: Neutral

DNLI reports a narrower-than-expected loss for the fourth quarter of 2024. Denali remains on track to submit a BLA for tividenofusp alfa for the treatment of MPS II (Hunter syndrome).

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image for news Denali Q4 Earnings Beat Estimates, Hunter Syndrome Drug in Focus
Denali Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Business Highlights
DNLI
Published: February 27, 2025 by: GlobeNewsWire
Sentiment: Neutral

SOUTH SAN FRANCISCO, Calif., Feb. 27, 2025 (GLOBE NEWSWIRE) -- Denali Therapeutics Inc. (Nasdaq: DNLI) today reported financial results for the fourth quarter and year ended December 31, 2024, and provided business highlights.

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image for news Denali Therapeutics Reports Fourth Quarter and Full Year 2024 Financial Results and Business Highlights

About Denali Therapeutics Inc. (DNLI)

  • IPO Date 2017-12-08
  • Website https://www.denalitherapeutics.com
  • Industry Biotechnology
  • CEO Dr. Ryan J. Watts Ph.D.
  • Employees 443

Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutic candidates for neurodegenerative diseases in the United States. It offers leucine-rich repeat kinase 2 (LRRK2) inhibitor product candidate, including BIIB122/DNL151, a small molecule inhibitor, which is in phase I and phase Ib clinical trials for the treatment of Parkinson's disease. The company also develops DNL310 that is in Phase I/II clinical trials for the treatment of hunter syndrome; DNL343, which is in phase 1 clinical trial the treatment of amyotrophic lateral sclerosis (ALS); AR443820/DNL788 completed a phase I clinical trial for the treatment of ALS, multiple sclerosis (MS), and Alzheimer's disease; and SAR443122/DNL758, which is in phase II clinical trial for the treatment of cutaneous lupus erythematosus. It has collaboration agreement with Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene; and a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG. to develop antisense therapies in the field of neurodegenerative diseases. The company was formerly known as SPR Pharma Inc. and changed its name to Denali Therapeutics Inc. in March 2015. Denali Therapeutics Inc. was incorporated in 2013 and is headquartered in South San Francisco, California.