CSTL

Castle Biosciences Inc
NASDAQHEALTHCAREDIAGNOSTICS & RESEARCH

Key Statistics

Market Cap
$1.09B
P/E Ratio
—
EPS
$-0.64
Beta
1.00
52W High
$44.28
52W Low
$17.72
50-Day MA
$31.01
200-Day MA
$29.17
Dividend Yield
—
Profit Margin
-5.43%
Forward P/E
—
PEG Ratio
—

About Castle Biosciences Inc

Castle Biosciences Inc. is a pioneering diagnostics firm that enhances patient care through advanced gene-expression profiling tests, particularly within the skin cancer sector, exemplified by its flagship product, DecisionDx®-Melanoma. This innovative test offers essential insights for risk stratification, enabling oncologists to make informed treatment decisions in managing melanoma. With a strong focus on precision medicine, coupled with an extensive research and development strategy, Castle Biosciences is poised for growth as it seeks to expand its offerings and meet critical clinical demands. By addressing the complexities inherent in oncology, the company not only aims to improve patient outcomes but also to generate substantial value for its investors.

Official WebsiteUSAFY End: December

Fundamentals

Revenue (TTM)$357.28M
Gross Profit (TTM)$276.03M
EBITDA$-16.52M
Operating Margin-2.96%
Return on Equity-4.20%
Return on Assets-1.36%
Revenue/Share (TTM)$12.04
Book Value$15.41
Price-to-Book2.27
Price-to-Sales (TTM)3.06
EV/Revenue2.34
EV/EBITDA42.95
Quarterly Earnings Growth (YoY)-51.60%
Quarterly Revenue Growth (YoY)20.10%
Shares Outstanding$30.55M
Float$27.14M
% Insiders2.42%
% Institutions91.01%

Historical Volatility

HV 10-Day
44.45%
HV 20-Day
35.83%
HV 30-Day
48.88%
HV 60-Day
49.92%
HV Rank
36.9%

Volatility is currently contracting

Analyst Ratings

Consensus ($45.11 target)
9
Buy

Latest News

New Study Highlights Clinical Need for Molecular Guidance in Atopic Dermatitis Treatment Selection, Reinforcing the Value of AdvanceAD-Tx™

Study data showed more than half of patients who used targeted systemic therapies modified treatment due to lack of efficacy Among patients surveyed in the study, 94% of those open to a new systemic therapy expressed interest in molecular testing to help identify a more effective treatment FRIENDSWOOD, Texas, Sept. 24, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of a new study highlighting the challenges patients with atopic dermatitis (AD) experience in achieving their treatment goals and strong patient interest in molecular testing to help guide systemic therapy selection.

PRNewsWire9/24/2026Neutral
New Decision Modeling Study Demonstrates TissueCypher® Significantly Improves Risk-Aligned Management for Patients with Barrett's Esophagus

Decision modeling study shows use of TissueCypher can nearly double appropriate escalation of care for patients with non-dysplastic Barrett's esophagus who later progress to cancer, while substantially reducing overuse of procedures in patients who do not progress FRIENDSWOOD, Texas, Sept. 15, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of a new decision modeling study showing that the TissueCypher® Barrett's Esophagus test (TSP-9) can help better align Barrett's esophagus (BE) management with a patient's individual risk of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

PRNewsWire9/15/2026Neutral
JAAD Publication Shows Improved Performance of DecisionDx®-SCC

DecisionDx-SCC shows enhanced performance with the integration of select clinicopathologic risk factors, providing a more precise result to support risk-aligned patient management DecisionDx-SCC's Class 1A (low risk) result demonstrated a 97.3% negative predictive value, supporting confidence in de-escalation decisions, while its Class 2B (highest risk) result identified patients most likely to benefit from adjuvant radiation therapy FRIENDSWOOD, Texas, Sept. 9, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the publication of a multi-center study in the Journal of the American Academy of Dermatology (JAAD) validating the integrated DecisionDx-SCC test result (i40-GEP) for patients with high-risk cutaneous squamous cell carcinoma (SCC).1 DecisionDx-SCC analyzes 40 genes to provide results related to prognosis and response to adjuvant radiation therapy (ART) based on an individual patient's tumor biology.

PRNewsWire9/9/2026Neutral
SciBase receives additional order from Castle Biosciences, advancing the collaboration

STOCKHOLM, Sept. 8, 2026 /PRNewswire/ -- SciBase Holding AB ("SciBase") (STO: SCIB), a leader in AI-based devices for detection and prevention in dermatology, today announces that it has received an additional order for an acceleration of the current, ongoing clinical study and preparations for a second clinical study under the collaboration with Castle Biosciences.

PRNewsWire9/8/2026Neutral
Castle Biosciences to Participate in Upcoming Investor Conferences

FRIENDSWOOD, Texas, Aug. 20, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that its executive management is scheduled to present a company overview at Baird's 2026 Global Healthcare Conference on Tuesday, Sept. 15, 2026, at 10:50 a.m.

PRNewsWire8/20/2026Neutral
Castle Biosciences Approved for Dual Listing on Nasdaq Texas

FRIENDSWOOD, Texas, Aug. 17, 2026 /PRNewswire/ -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced that it has been approved to have its common stock dually listed on Nasdaq Texas, a new exchange headquartered in Dallas. Castle will maintain its primary listing on The Nasdaq Global Market, and its common stock is expected to begin listing on Nasdaq Texas today under its existing ticker symbol, "CSTL.

PRNewsWire8/17/2026Neutral

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Data last updated: 9/26/2026