Axsome Therapeutics, Inc. (AXSM)

US — Healthcare Sector
Peers: NUVL  MTSR  MRUS  ABVX  CYTK  RYTM  ARWR  CRSP  PCVX  JAZZ 

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Key Metrics & Ratings

  • symbol AXSM
  • Rev/Share 11.2204
  • Book/Share 1.4739
  • PB 93.4937
  • Debt/Equity 2.9311
  • CurrentRatio 1.5691
  • ROIC -0.5573

 

  • MktCap 6946856280.0
  • FreeCF/Share -2.0118
  • PFCF -69.0316
  • PE -30.0314
  • Debt/Assets 0.3229
  • DivYield 0
  • ROE -3.5721

 

  • Rating C-
  • Score 1
  • Recommendation Strong Sell
  • P/E Score 1
  • DCF Score 3
  • P/B Score 1
  • D/E Score 1

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Initiation AXSM B. Riley Securities -- Buy -- $179 Oct. 1, 2025
Resumed AXSM Wells Fargo -- Overweight -- $163 Sept. 3, 2025
Resumed AXSM Morgan Stanley -- Overweight -- $190 July 3, 2025
Initiation AXSM Oppenheimer -- Outperform -- $185 June 3, 2025
Initiation AXSM Jefferies -- Buy -- $200 April 7, 2025
Initiation AXSM Deutsche Bank -- Buy -- $176 Feb. 11, 2025
Reiterated AXSM Mizuho -- Outperform $124 $122 Dec. 31, 2024
Initiation AXSM Wells Fargo -- Overweight -- $140 Sept. 3, 2024

News

Axsome: Alzheimer's Disease Agitation sNDA Adds Optionality, Not A Thesis Changer
AXSM
Published: November 05, 2025 by: Seeking Alpha
Sentiment: Positive

Axsome Therapeutics remains a 'Sell' due to an undifferentiated CNS pipeline, heavy SG&A, and ongoing net losses despite revenue growth. Auvelity's sales growth appears largely marketing-driven and competes in a crowded, generic-heavy depression market. AXS-05 for Alzheimer's agitation offers some promise as a non-antipsychotic, but real-world adoption and blockbuster potential are limited.

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image for news Axsome: Alzheimer's Disease Agitation sNDA Adds Optionality, Not A Thesis Changer
AXSM Q3 Loss Wider Than Expected, Revenues Surge Y/Y on Auvelity Sales
AXSM
Published: November 04, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome incurs wider-than-expected Q3 loss but revenues soar 63% on booming Auvelity sales, with Sunosi and the newest drug, Symbravo, aiding the top line.

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image for news AXSM Q3 Loss Wider Than Expected, Revenues Surge Y/Y on Auvelity Sales
Axsome Therapeutics, Inc. (AXSM) Q3 2025 Earnings Call Transcript
AXSM
Published: November 03, 2025 by: Seeking Alpha
Sentiment: Neutral

Axsome Therapeutics, Inc. ( AXSM ) Q3 2025 Earnings Call November 3, 2025 8:00 AM EST Company Participants Darren Opland - Director of Corporate Communications Herriot Tabuteau - Founder, Chairman, CEO & President Nick Pizzie - Chief Financial Officer Ari Maizel - Chief Commercial Officer Mark Jacobson - Chief Operating Officer Conference Call Participants Leonid Timashev - RBC Capital Markets, Research Division Basma Radwan Ibrahim - Leerink Partners LLC, Research Division Pete Stavropoulos - Cantor Fitzgerald & Co., Research Division Sean Laaman - Morgan Stanley, Research Division Ashwani Verma - UBS Investment Bank, Research Division Lin Tsai - Jefferies LLC, …

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image for news Axsome Therapeutics, Inc. (AXSM) Q3 2025 Earnings Call Transcript
Axsome Therapeutics (AXSM) May Report Negative Earnings: Know the Trend Ahead of Next Week's Release
AXSM
Published: October 27, 2025 by: Zacks Investment Research
Sentiment: Negative

Axsome (AXSM) doesn't possess the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

Read More
image for news Axsome Therapeutics (AXSM) May Report Negative Earnings: Know the Trend Ahead of Next Week's Release
Halper Sadeh LLC Encourages Axsome Therapeutics, Inc. Shareholders to Contact the Firm to Discuss Their Rights
AXSM
Published: October 24, 2025 by: Business Wire
Sentiment: Neutral

NEW YORK--(BUSINESS WIRE)--Halper Sadeh LLC, an investor rights law firm, is investigating whether certain officers and directors of Axsome Therapeutics, Inc. (NASDAQ: AXSM) breached their fiduciary duties to shareholders. If you currently own Axsome stock and are a long-term shareholder, you may be able to seek corporate governance reforms, the return of funds back to the company, a court-approved financial incentive award, or other relief and benefits. Please click here to learn more about yo.

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image for news Halper Sadeh LLC Encourages Axsome Therapeutics, Inc. Shareholders to Contact the Firm to Discuss Their Rights
Can Auvelity Drive Axsome's Growth Through the Rest of 2025?
AXSM
Published: September 30, 2025 by: Zacks Investment Research
Sentiment: Positive

AXSM's Auvelity drives 82% sales growth in the first half of 2025, with label expansion studies and other marketed products bolstering its CNS drug portfolio.

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image for news Can Auvelity Drive Axsome's Growth Through the Rest of 2025?
Axsome Therapeutics Highlights Data Across Its Leading Neuroscience Pipeline at Psych Congress 2025
AXSM
Published: September 17, 2025 by: GlobeNewsWire
Sentiment: Neutral

Six poster presentations showcase clinical and real-world data in major depressive disorder, Alzheimer's disease agitation, narcolepsy, and obstructive sleep apnea Six poster presentations showcase clinical and real-world data in major depressive disorder, Alzheimer's disease agitation, narcolepsy, and obstructive sleep apnea

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image for news Axsome Therapeutics Highlights Data Across Its Leading Neuroscience Pipeline at Psych Congress 2025
Why Is Axsome (AXSM) Up 19.2% Since Last Earnings Report?
AXSM
Published: September 03, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome (AXSM) reported earnings 30 days ago. What's next for the stock?

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image for news Why Is Axsome (AXSM) Up 19.2% Since Last Earnings Report?
Axsome Shares Up 20% in a Month: How Should You Play the Stock?
AXSM
Published: August 29, 2025 by: Zacks Investment Research
Sentiment: Positive

AXSM shares rise 20.2% in a month, powered by booming Auvelity sales and a growing CNS drug pipeline.

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image for news Axsome Shares Up 20% in a Month: How Should You Play the Stock?
Axsome Therapeutics to Participate in Upcoming Investor Conferences
AXSM
Published: August 27, 2025 by: GlobeNewsWire
Sentiment: Neutral

NEW YORK, Aug. 27, 2025 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that it will participate in the following upcoming investor conferences in September:

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image for news Axsome Therapeutics to Participate in Upcoming Investor Conferences
Axsome Therapeutics Analysts Increase Their Forecasts After Q2 Earnings
AXSM
Published: August 05, 2025 by: Benzinga
Sentiment: Positive

Axsome Therapeutics, Inc. AXSM reported better-than-expected second-quarter financial results on Monday.

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image for news Axsome Therapeutics Analysts Increase Their Forecasts After Q2 Earnings
AXSM Q2 Loss Narrower Than Expected, Auvelity Drives Revenues Y/Y
AXSM
Published: August 05, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome posts narrower second-quarter loss and 72% revenue surge, driven by strong Auvelity sales.

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image for news AXSM Q2 Loss Narrower Than Expected, Auvelity Drives Revenues Y/Y
Axsome Therapeutics, Inc. (AXSM) Q2 2025 Earnings Call Transcript
AXSM
Published: August 04, 2025 by: Seeking Alpha
Sentiment: Neutral

Axsome Therapeutics, Inc. (NASDAQ:AXSM ) Q2 2025 Earnings Conference Call August 4, 2025 8:00 AM ET Company Participants Ari Maizel - Chief Commercial Officer Darren Opland - Corporate Participant Herriot Tabuteau - Founder, Chairman, CEO & President Nick Pizzie - Chief Financial Officer Conference Call Participants Ashwani Verma - UBS Investment Bank, Research Division Asim Rana - Truist Securities, Inc., Research Division David A. Amsellem - Piper Sandler & Co., Research Division David Timothy Hoang - Deutsche Bank AG, Research Division Graig C.

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image for news Axsome Therapeutics, Inc. (AXSM) Q2 2025 Earnings Call Transcript
Here's What Key Metrics Tell Us About Axsome (AXSM) Q2 Earnings
AXSM
Published: August 04, 2025 by: Zacks Investment Research
Sentiment: Neutral

While the top- and bottom-line numbers for Axsome (AXSM) give a sense of how the business performed in the quarter ended June 2025, it could be worth looking at how some of its key metrics compare to Wall Street estimates and year-ago values.

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image for news Here's What Key Metrics Tell Us About Axsome (AXSM) Q2 Earnings
Axsome Therapeutics (AXSM) Reports Q2 Loss, Beats Revenue Estimates
AXSM
Published: August 04, 2025 by: Zacks Investment Research
Sentiment: Neutral

Axsome Therapeutics (AXSM) came out with a quarterly loss of $0.92 per share versus the Zacks Consensus Estimate of a loss of $1. This compares to a loss of $1.24 per share a year ago.

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image for news Axsome Therapeutics (AXSM) Reports Q2 Loss, Beats Revenue Estimates
Axsome Therapeutics (AXSM) Expected to Beat Earnings Estimates: Can the Stock Move Higher?
AXSM
Published: July 28, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome (AXSM) possesses the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

Read More
image for news Axsome Therapeutics (AXSM) Expected to Beat Earnings Estimates: Can the Stock Move Higher?
Axsome: Some Recent Setbacks, Some Recent Wins -- Still A Buy
AXSM
Published: July 25, 2025 by: Seeking Alpha
Sentiment: Positive

Axsome's valuation is driven by its promising pipeline, with Auvelity as a proven commercial success and Symbravo and AXS-12 showing solid potential. Recent setbacks include the FDA's refusal to file AXS-14 and Sunosi's failure in MDD studies, but ADHD data for Sunosi is encouraging. I estimate $3bn in peak revenues by the mid-2030s, which supports a Buy rating despite management's more ambitious projections.

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image for news Axsome: Some Recent Setbacks, Some Recent Wins -- Still A Buy
Axsome Therapeutics Hosts Frontiers in Brain Health R&D Day Reviewing Industry-Leading Late-Stage CNS Pipeline
AXSM
Published: July 21, 2025 by: GlobeNewsWire
Sentiment: Neutral

Comprehensive review of broad pipeline targeting Alzheimer's disease agitation, depression, narcolepsy, fibromyalgia, ADHD, and smoking cessation, with new data analyses

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image for news Axsome Therapeutics Hosts Frontiers in Brain Health R&D Day Reviewing Industry-Leading Late-Stage CNS Pipeline
Why Is Axsome (AXSM) Down 1.8% Since Last Earnings Report?
AXSM
Published: June 04, 2025 by: Zacks Investment Research
Sentiment: Negative

Axsome (AXSM) reported earnings 30 days ago. What's next for the stock?

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image for news Why Is Axsome (AXSM) Down 1.8% Since Last Earnings Report?
Axsome Therapeutics Q1: Marketing-Driven Growth Masks Profitability Concerns
AXSM
Published: May 06, 2025 by: Seeking Alpha
Sentiment: Positive

Axsome Therapeutics reported strong Q1 2025 earnings, with revenue and EPS beats driven by Auvelity and Sunosi, despite high SG&A expenses and net loss. Auvelity shows promising growth in the competitive depression market, but its success is heavily reliant on aggressive marketing and significant spending. Upcoming launches and regulatory submissions for Symbravo, AXS-14, AXS-05, and AXS-12 face stiff competition and potential regulatory hurdles.

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image for news Axsome Therapeutics Q1: Marketing-Driven Growth Masks Profitability Concerns
AXSM Q1 Loss Narrower Than Expected, Auvelity Drives Revenues Y/Y
AXSM
Published: May 06, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome reports better-than-expected first quarter 2025 results. Net product revenues surge year over year on strong Auvelity sales.

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image for news AXSM Q1 Loss Narrower Than Expected, Auvelity Drives Revenues Y/Y
Axsome Therapeutics, Inc. (AXSM) Q1 2025 Earnings Call Transcript
AXSM
Published: May 05, 2025 by: Seeking Alpha
Sentiment: Neutral

Axsome Therapeutics, Inc. (NASDAQ:AXSM ) Q1 2025 Earnings Conference Call May 5, 2025 8:00 AM ET Company Participants Darren Opland - Director, Corporate Communications Herriot Tabuteau - CEO Nick Pizzie - CFO Ari Maizel - Chief Commercial Officer Mark Jacobson - COO Hunter Murdock - General Counsel Conference Call Participants Leonid Timashev - RBC Capital Markets Marc Goodman - Leerink Partners Andrew Tsai - Jefferies Ash Verma - UBS Ram Selvaraju - H.C. Wainwright Charles Duncan - Cantor Fitzgerald David Amsellem - Piper Sandler David Hoang - Deutsche Bank Joon Lee - Truist Securities Cerena Chen - Wells Fargo Jason …

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image for news Axsome Therapeutics, Inc. (AXSM) Q1 2025 Earnings Call Transcript
Axsome Therapeutics Clocks Around 60% Topline Growth In Q1
AXSM
Published: May 05, 2025 by: Benzinga
Sentiment: Positive

Axsome Therapeutics Inc AXSM on Monday reported first-quarter 2025 revenues of $121.5 million, up from $75 million a year ago, beating the consensus of $119.87 million.

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image for news Axsome Therapeutics Clocks Around 60% Topline Growth In Q1
Axsome (AXSM) Q1 Earnings: How Key Metrics Compare to Wall Street Estimates
AXSM
Published: May 05, 2025 by: Zacks Investment Research
Sentiment: Neutral

While the top- and bottom-line numbers for Axsome (AXSM) give a sense of how the business performed in the quarter ended March 2025, it could be worth looking at how some of its key metrics compare to Wall Street estimates and year-ago values.

Read More
image for news Axsome (AXSM) Q1 Earnings: How Key Metrics Compare to Wall Street Estimates
Axsome Therapeutics (AXSM) Reports Q1 Loss, Tops Revenue Estimates
AXSM
Published: May 05, 2025 by: Zacks Investment Research
Sentiment: Negative

Axsome Therapeutics (AXSM) came out with a quarterly loss of $0.80 per share versus the Zacks Consensus Estimate of a loss of $1.26. This compares to loss of $1.09 per share a year ago.

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image for news Axsome Therapeutics (AXSM) Reports Q1 Loss, Tops Revenue Estimates
Axsome Therapeutics to Participate in Upcoming Investor Conferences
AXSM
Published: April 22, 2025 by: GlobeNewsWire
Sentiment: Neutral

NEW YORK, April 22, 2025 (GLOBE NEWSWIRE) -- Axsome Therapeutics, Inc. (NASDAQ: AXSM), a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) disorders, today announced that it will participate in four upcoming investor conferences in May:

Read More
image for news Axsome Therapeutics to Participate in Upcoming Investor Conferences
Kuehn Law Encourages Investors of Five Below, Inc. to Contact Law Firm
AXSM, FIVE
Published: April 16, 2025 by: GlobeNewsWire
Sentiment: Neutral

NEW YORK, April 16, 2025 (GLOBE NEWSWIRE) -- Kuehn Law, PLLC, a shareholder litigation law firm, is investigating whether certain officers and directors of Five Below, Inc. (NASDAQ: FIVE) breached their fiduciary duties to shareholders.

Read More
image for news Kuehn Law Encourages Investors of Five Below, Inc. to Contact Law Firm
Kuehn Law Encourages Investors of Amylyx Pharmaceuticals, Inc. to Contact Law Firm
AMLX, AXSM
Published: April 16, 2025 by: GlobeNewsWire
Sentiment: Neutral

NEW YORK, April 16, 2025 (GLOBE NEWSWIRE) -- Kuehn Law, PLLC, a shareholder litigation law firm, is investigating whether certain officers and directors of Amylyx Pharmaceuticals, Inc. (NASDAQ: AMLX) breached their fiduciary duties to shareholders.

Read More
image for news Kuehn Law Encourages Investors of Amylyx Pharmaceuticals, Inc. to Contact Law Firm
Axsome (AXSM) Moves 4.2% Higher: Will This Strength Last?
AXSM
Published: April 10, 2025 by: Zacks Investment Research
Sentiment: Positive

Axsome (AXSM) saw its shares surge in the last session with trading volume being higher than average. The latest trend in earnings estimate revisions could translate into further price increase in the near term.

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image for news Axsome (AXSM) Moves 4.2% Higher: Will This Strength Last?
Kuehn Law Encourages Investors of Axsome Therapeutics, Inc. to Contact Law Firm
AXSM
Published: April 08, 2025 by: PRNewsWire
Sentiment: Neutral

NEW YORK , April 8, 2025 /PRNewswire/ -- Kuehn Law, PLLC, a shareholder litigation law firm, is investigating whether certain officers and directors of Axsome Therapeutics, Inc. (NASDAQ: AXSM) breached their fiduciary duties to shareholders. According to a federal securities lawsuit, Insiders at Axsome caused the company to misrepresent or fail to disclose (i) Axsome's chemistry, manufacturing, and control ("CMC") practices were deficient with respect to AXS-07 and its manufacturing process; (ii) as a result, Axsome was unlikely to submit the AXS-07 NDA on its initially represented timeline; (iii) the foregoing CMC issues remained unresolved at the time that the …

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image for news Kuehn Law Encourages Investors of Axsome Therapeutics, Inc. to Contact Law Firm

About Axsome Therapeutics, Inc. (AXSM)

  • IPO Date 2015-11-19
  • Website https://www.axsome.com
  • Industry Biotechnology
  • CEO Herriot Tabuteau
  • Employees 712

Axsome Therapeutics, Inc., a biopharmaceutical company, engages in the development of novel therapies for central nervous system (CNS) disorders in the United States. The company's product pipeline includes AXS-05, a therapeutic for the treatment of major depressive disorder and resistant depression disorders; and that is in the Phase III clinical trial to treat Alzheimer's disease agitation, as well as that has completed phase II clinical trial for the treatment of smoking cessation. It is also developing AXS-07, a novel, oral, rapidly absorbed, multi-mechanistic, and investigational medicine that has completed two Phase III trials for the acute treatment of migraine; AXS-12, a selective and potent norepinephrine reuptake inhibitor, which is in Phase III trial to treat narcolepsy; and AXS-14, a novel, oral, and investigational medicine that is in Phase III trial for the treatment of fibromyalgia. Axsome Therapeutics, Inc. has a research collaboration agreement with Duke University for evaluating AXS-05 in smoking cessation. The company was incorporated in 2012 and is based in New York, New York.