Apellis Pharmaceuticals, Inc. (APLS)

US — Healthcare Sector
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Key Metrics & Ratings

  • symbol APLS
  • Rev/Share 6.1843
  • Book/Share 1.309
  • PB 13.3004
  • Debt/Equity 2.8594
  • CurrentRatio 4.0797
  • ROIC -0.2946

 

  • MktCap 2188123620.0
  • FreeCF/Share -0.067
  • PFCF -260.1502
  • PE -9.7646
  • Debt/Assets 0.5816
  • DivYield 0
  • ROE -1.0006

 

  • Rating D+
  • Score 1
  • Recommendation Strong Sell
  • P/E Score 1
  • DCF Score 1
  • P/B Score 1
  • D/E Score 1

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Downgrade APLS BofA Securities Buy Neutral -- $23 May 9, 2025
Downgrade APLS Raymond James Strong Buy Outperform -- $52 May 9, 2025
Initiation APLS Cantor Fitzgerald -- Overweight -- $44 April 29, 2025
Downgrade APLS Goldman Buy Neutral -- $36 Dec. 17, 2024
Initiation APLS Scotiabank -- Sector Outperform -- -- Oct. 16, 2024
Initiation APLS William Blair -- Outperform -- -- Oct. 16, 2024

News

Apellis Pharmaceuticals: Have Some Patience
APLS
Published: May 20, 2025 by: Seeking Alpha
Sentiment: Positive

Apellis Pharmaceuticals is a Buy due to the significant FCF potential of SYFOVRE® and EMPAVELI®, with SYFOVRE® projected to exceed $1bn in annual sales by 2028. SYFOVRE® has shown efficacy in slowing GA progression and saw a 122% YoY sales increase in 2024, despite initial rollout issues. EMPAVELI® offers moderate sales and is in trials for additional indications, promising incremental cash flows and contributing to EBITDA positivity by 2026.

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image for news Apellis Pharmaceuticals: Have Some Patience
Apellis' Q1 Earnings and Revenues Miss Estimates, Stock Down
APLS
Published: May 08, 2025 by: Zacks Investment Research
Sentiment: Negative

APLS stock falls as it reports weaker-than-expected first-quarter 2025 results, wherein both earnings and revenues miss estimates.

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image for news Apellis' Q1 Earnings and Revenues Miss Estimates, Stock Down
Apellis Pharmaceuticals, Inc. (APLS) Q1 2025 Earnings Call Transcript
APLS
Published: May 07, 2025 by: Seeking Alpha
Sentiment: Neutral

Apellis Pharmaceuticals, Inc. (NASDAQ:APLS ) Q1 2025 Earnings Conference Call May 7, 2025 8:30 AM ET Company Participants Tracy Vineis – Vice President-Communications Cedric Francois – Co-Founder and Chief Executive Officer Tim Sullivan – Chief Financial Officer David Acheson – Executive Vice President-Commercial Caroline Baumal – Chief Medical Officer Conference Call Participants Jon Miller – Evercore Tazeen Ahmad – Bank of America Securities Anupam Rama – JPM Steve Seedhouse – Cantor Colleen Kusy – Baird Eliana Merle – UBS Annabel Samimy – Stifel Biren Amin – Piper Sandler Yigal Nochomovitz – Citigroup Douglas Tsao – H.C. Wainwright Lachlan Hanbury-Brown – …

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image for news Apellis Pharmaceuticals, Inc. (APLS) Q1 2025 Earnings Call Transcript
Apellis Pharmaceuticals (APLS) Reports Q1 Earnings: What Key Metrics Have to Say
APLS
Published: May 07, 2025 by: Zacks Investment Research
Sentiment: Positive

The headline numbers for Apellis Pharmaceuticals (APLS) give insight into how the company performed in the quarter ended March 2025, but it may be worthwhile to compare some of its key metrics to Wall Street estimates and the year-ago actuals.

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image for news Apellis Pharmaceuticals (APLS) Reports Q1 Earnings: What Key Metrics Have to Say
Apellis Pharmaceuticals, Inc. (APLS) Reports Q1 Loss, Lags Revenue Estimates
APLS
Published: May 07, 2025 by: Zacks Investment Research
Sentiment: Negative

Apellis Pharmaceuticals, Inc. (APLS) came out with a quarterly loss of $0.74 per share versus the Zacks Consensus Estimate of a loss of $0.36. This compares to loss of $0.54 per share a year ago.

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image for news Apellis Pharmaceuticals, Inc. (APLS) Reports Q1 Loss, Lags Revenue Estimates
Apellis Announces Craig Wheeler to Join the Board of Directors
APLS
Published: April 21, 2025 by: GlobeNewsWire
Sentiment: Neutral

WALTHAM, Mass., April 21, 2025 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (Nasdaq: APLS) today announced that Craig Wheeler, founder and chief executive officer of Headwaters Biotech Advisors, will join the Apellis Board of Directors, effective immediately. Mr. Wheeler is a highly accomplished executive with more than 30 years of leadership experience across the biopharmaceutical industry.

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image for news Apellis Announces Craig Wheeler to Join the Board of Directors
FDA Reviews Kidney Disease Drug From Apellis Pharmaceuticals
APLS
Published: April 01, 2025 by: Benzinga
Sentiment: Positive

The U.S. Food and Drug Administration (FDA) on Tuesday accepted and granted Priority Review designation to Apellis Pharmaceuticals, Inc.'s APLS supplemental New Drug Application (sNDA) for Empaveli (pegcetacoplan) for C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN).

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image for news FDA Reviews Kidney Disease Drug From Apellis Pharmaceuticals
Apellis Pharmaceuticals: A Mixed Bag
APLS
Published: March 05, 2025 by: Seeking Alpha
Sentiment: Positive

Commerical stage Apellis Pharmaceuticals, Inc. recently reported Q4 results that beat expectations. The company posted impressive revenue growth and cost reduction in FY2024. It is a bit of a complicated tale around this mid-cap, but the company looks set to move to profitability with the funding it has on hand.

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image for news Apellis Pharmaceuticals: A Mixed Bag
Apellis Lead Drug Pegcetacoplan Represents Differentiated Asset: JP Morgan Analyst
APLS
Published: March 05, 2025 by: Benzinga
Sentiment: Positive

Last week, Apellis Pharmaceuticals Inc APLS reported a fourth-quarter earnings loss of 29 cents per share, beating the consensus loss of 37 cents. Sales increased 45.2% to $212.5 million, beating the consensus of $198.35 million.

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image for news Apellis Lead Drug Pegcetacoplan Represents Differentiated Asset: JP Morgan Analyst
Apellis Q4 Loss Narrower Than Expected, Syfovre Sales Drive Revenues
APLS
Published: March 03, 2025 by: Zacks Investment Research
Sentiment: Positive

APLS reports better-than-expected fourth-quarter 2024 results, wherein both earnings and revenues beat estimates, driven by strong sales of Syfovre.

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image for news Apellis Q4 Loss Narrower Than Expected, Syfovre Sales Drive Revenues
Apellis Pharmaceuticals to Present at the TD Cowen 45th Annual Health Care Conference
APLS
Published: February 24, 2025 by: GlobeNewsWire
Sentiment: Neutral

WALTHAM, Mass., Feb. 24, 2025 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (Nasdaq: APLS) today announced that the company will present at the TD Cowen 45th Annual Health Care Conference on Monday, March 3, 2025, at 10:30 a.m. ET.

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image for news Apellis Pharmaceuticals to Present at the TD Cowen 45th Annual Health Care Conference
Apellis Pharmaceuticals, Inc. (APLS) May Report Negative Earnings: Know the Trend Ahead of Next Week's Release
APLS
Published: February 21, 2025 by: Zacks Investment Research
Sentiment: Negative

Apellis Pharmaceuticals (APLS) doesn't possess the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

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image for news Apellis Pharmaceuticals, Inc. (APLS) May Report Negative Earnings: Know the Trend Ahead of Next Week's Release
Apellis and Sobi Announce EMA Validation of Indication Extension Application for Aspaveli® (pegcetacoplan) for C3G and Primary IC-MPGN
APLS
Published: February 20, 2025 by: GlobeNewsWire
Sentiment: Neutral

WALTHAM, Mass. and STOCKHOLM, Sweden, Feb. 20, 2025 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals, Inc. (Nasdaq: APLS) and Sobi® (STO:SOBI) today announced the European Medicines Agency (EMA) has validated an indication extension application for Aspaveli® (pegcetacoplan) for the treatment of C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN), which are rare, chronic kidney diseases with no approved treatments.

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image for news Apellis and Sobi Announce EMA Validation of Indication Extension Application for Aspaveli® (pegcetacoplan) for C3G and Primary IC-MPGN
Apellis Pharmaceuticals to Host Conference Call on February 28, 2025, to Discuss Fourth Quarter and Full Year 2024 Financial Results
APLS
Published: February 14, 2025 by: GlobeNewsWire
Sentiment: Neutral

WALTHAM, Mass., Feb. 14, 2025 (GLOBE NEWSWIRE) -- Apellis Pharmaceuticals , Inc. (Nasdaq: APLS) today announced that the company will host a conference call and webcast to discuss its fourth quarter and full year 2024 financial results on Friday, February 28, 2025, at 8:30 a.m.

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image for news Apellis Pharmaceuticals to Host Conference Call on February 28, 2025, to Discuss Fourth Quarter and Full Year 2024 Financial Results

About Apellis Pharmaceuticals, Inc. (APLS)

  • IPO Date 2017-11-09
  • Website https://www.apellis.com
  • Industry Biotechnology
  • CEO Dr. Cedric Francois M.D., Ph.D.
  • Employees 705

Apellis Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the discovery, development, and commercialization of therapeutic compounds through the inhibition of the complement system for autoimmune and inflammatory diseases. The company's lead product candidate is pegcetacoplan that is in Phase III clinical trials for the treatment of geographic atrophy (GA) in age-related macular degeneration and paroxysmal nocturnal hemoglobinuria (PNH) diseases. It also develops EMPAVELI (systemic pegcetacoplan) for the treatment of cold agglutinin disease (CAD), and hematopoietic stem cell transplantation-associated thrombotic microangiopathy (HSCT-TMA) in hematology; C3 glomerulopathy (C3G), and immune complex membranoproliferative glomerulonephritis (IC-MPGN) in nephrology; and amyotrophic lateral sclerosis (ALS) in neurology. In addition, the company develops APL-2006, a bispecific C3 and VEGF inhibitor for treating complement-mediated disorders; APL-1030, a C3 inhibitor for the treatment of multiple neurodegenerative diseases; and the combination of EMPAVELI and a small interfering RNA, or siRNA for reducing the production of C3 proteins by the liver. It has a collaboration and license agreement with Swedish Orphan Biovitrum AB (publ) to co-develop pegcetacoplan; and a research collaboration with Beam Therapeutics Inc. focused on the use of Beam's base editing technology to discover new treatments for complement-driven diseases. Apellis Pharmaceuticals, Inc. was incorporated in 2009 and is based in Waltham, Massachusetts.