Madrigal Pharmaceuticals, Inc. (MDGL)

US — Healthcare Sector
Peers: RNA  JAZZ  MRNA  CAI  RYTM  ABVX  TECH  EXEL  BMRN  BAX 

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Key Metrics & Ratings

  • symbol MDGL
  • Rev/Share 42.7204
  • Book/Share 26.8646
  • PB 16.2962
  • Debt/Equity 0.588
  • CurrentRatio 4.0149
  • ROIC -0.3158

 

  • MktCap 9942832562.0
  • FreeCF/Share -8.4701
  • PFCF -52.3252
  • PE -34.0689
  • Debt/Assets 0.2813
  • DivYield 0
  • ROE -0.4376

 

  • Rating C-
  • Score 1
  • Recommendation Strong Sell
  • P/E Score 1
  • DCF Score 3
  • P/B Score 1
  • D/E Score 2

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Initiation MDGL Barclays -- Overweight -- $964 Jan. 28, 2026
Downgrade MDGL Wolfe Research Outperform Peer Perform -- -- Jan. 6, 2026
Upgrade MDGL Cantor Fitzgerald Neutral Overweight -- -- Nov. 5, 2025
Upgrade MDGL BofA Securities Underperform Neutral -- $445 Nov. 3, 2025
Initiation MDGL Truist -- Buy -- $580 Oct. 15, 2025
Resumed MDGL H.C. Wainwright -- Buy -- $500 Sept. 4, 2025
Upgrade MDGL B. Riley Securities Neutral Buy $236 $422 Feb. 28, 2025
Reiterated MDGL H.C. Wainwright -- Buy $400 $405 Feb. 27, 2025

News

Madrigal Q4 Earnings Miss, MASH Drug Sales Drive Top Line, Stock Down
MDGL
Published: February 20, 2026 by: Zacks Investment Research
Sentiment: Negative

MDGL swings to a wider Q4 loss as expenses surge, but Rezdiffra sales top estimates and fuel revenue growth. The stock slides 11% in response to the mixed nature of the results.

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image for news Madrigal Q4 Earnings Miss, MASH Drug Sales Drive Top Line, Stock Down
Madrigal Pharmaceuticals, Inc. (MDGL) Q4 2025 Earnings Call Transcript
MDGL
Published: February 19, 2026 by: Seeking Alpha
Sentiment: Neutral

Madrigal Pharmaceuticals, Inc. (MDGL) Q4 2025 Earnings Call Transcript

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image for news Madrigal Pharmaceuticals, Inc. (MDGL) Q4 2025 Earnings Call Transcript
Madrigal (MDGL) Reports Q4 Loss, Beats Revenue Estimates
MDGL
Published: February 19, 2026 by: Zacks Investment Research
Sentiment: Neutral

Madrigal (MDGL) came out with a quarterly loss of $2.57 per share versus the Zacks Consensus Estimate of $0.04. This compares to a loss of $2.71 per share a year ago.

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image for news Madrigal (MDGL) Reports Q4 Loss, Beats Revenue Estimates
What to Expect From These Drug/Biotech Players This Earnings Season?
BHC, BMRN, FOLD, INSM, MDGL
Published: February 16, 2026 by: Zacks Investment Research
Sentiment: Neutral

Let's take a closer look at what awaits Bausch Health, Amicus Therapeutics, BioMarin Pharmaceutical, Insmed and Madrigal Pharmaceuticals as they prepare to report quarterly results this week.

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image for news What to Expect From These Drug/Biotech Players This Earnings Season?
MDGL Strengthens MASH Franchise With New Genetic Approaches
MDGL
Published: February 12, 2026 by: Zacks Investment Research
Sentiment: Positive

Madrigal inks $4.4B siRNA licensing deal with Ribo in $60M upfront pact, adding preclinical candidates, expanding MASH pipeline and eyeing FDA filings in 2026.

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image for news MDGL Strengthens MASH Franchise With New Genetic Approaches
Madrigal (MDGL) Earnings Expected to Grow: What to Know Ahead of Next Week's Release
MDGL
Published: February 12, 2026 by: Zacks Investment Research
Sentiment: Neutral

Madrigal (MDGL) doesn't possess the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

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image for news Madrigal (MDGL) Earnings Expected to Grow: What to Know Ahead of Next Week's Release
MKKGY or MDGL: Which Is the Better Value Stock Right Now?
MDGL, MKKGY
Published: February 11, 2026 by: Zacks Investment Research
Sentiment: Neutral

Investors looking for stocks in the Medical - Drugs sector might want to consider either Merck KGaA (MKKGY) or Madrigal (MDGL). But which of these two stocks presents investors with the better value opportunity right now?

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image for news MKKGY or MDGL: Which Is the Better Value Stock Right Now?
STVN or MDGL: Which Is the Better Value Stock Right Now?
MDGL, STVN
Published: January 26, 2026 by: Zacks Investment Research
Sentiment: Neutral

Investors looking for stocks in the Medical - Drugs sector might want to consider either Stevanato Group (STVN) or Madrigal (MDGL). But which of these two stocks offers value investors a better bang for their buck right now?

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image for news STVN or MDGL: Which Is the Better Value Stock Right Now?
MDGL Secures Exclusive Global Right for MASH Treatment From PFE
MDGL
Published: January 12, 2026 by: Zacks Investment Research
Sentiment: Neutral

Madrigal Pharmaceuticals obtains global rights to Pfizer's ervogastat. It intends to pair it with Rezdiffra to advance combination therapies for MASH.

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image for news MDGL Secures Exclusive Global Right for MASH Treatment From PFE
UTHR or MDGL: Which Is the Better Value Stock Right Now?
MDGL, UTHR
Published: January 08, 2026 by: Zacks Investment Research
Sentiment: Positive

Investors interested in stocks from the Medical - Drugs sector have probably already heard of United Therapeutics (UTHR) and Madrigal (MDGL). But which of these two companies is the best option for those looking for undervalued stocks?

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image for news UTHR or MDGL: Which Is the Better Value Stock Right Now?
Madrigal (MDGL) Up 21.9% Since Last Earnings Report: Can It Continue?
MDGL
Published: December 04, 2025 by: Zacks Investment Research
Sentiment: Positive

Madrigal (MDGL) reported earnings 30 days ago. What's next for the stock?

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image for news Madrigal (MDGL) Up 21.9% Since Last Earnings Report: Can It Continue?
Madrigal Pharmaceuticals, Inc. (MDGL) Presents at Jefferies London Healthcare Conference 2025 Transcript
MDGL
Published: November 20, 2025 by: Seeking Alpha
Sentiment: Neutral

Madrigal Pharmaceuticals, Inc. ( MDGL ) Jefferies London Healthcare Conference 2025 November 20, 2025 3:30 AM EST Company Participants William Sibold - CEO, President & Director Mardi Dier - Executive VP & CFO David Soergel - Executive VP & Chief Medical Officer Conference Call Participants Akash Tewari - Jefferies LLC, Research Division Presentation Akash Tewari Jefferies LLC, Research Division Good morning, everyone. We've made it to our last day of our London Healthcare Conference.

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image for news Madrigal Pharmaceuticals, Inc. (MDGL) Presents at Jefferies London Healthcare Conference 2025 Transcript
Madrigal Q3 Earnings Miss, MASH Drug Sales Drive Top Line, Stock Up
MDGL
Published: November 05, 2025 by: Zacks Investment Research
Sentiment: Negative

MDGL's wider Q3 loss fails to deter investors, as soaring Rezdiffra sales drive revenues past estimates and lift the stock.

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image for news Madrigal Q3 Earnings Miss, MASH Drug Sales Drive Top Line, Stock Up
Madrigal Pharmaceuticals, Inc. (MDGL) Q3 2025 Earnings Call Transcript
MDGL
Published: November 04, 2025 by: Seeking Alpha
Sentiment: Neutral

Madrigal Pharmaceuticals, Inc. ( MDGL ) Q3 2025 Earnings Call November 4, 2025 8:00 AM EST Company Participants Tina Ventura - Chief Investor Relations Officer William Sibold - CEO, President & Director David Soergel - Executive VP & Chief Medical Officer Mardi Dier - Executive VP & CFO Conference Call Participants Yasmeen Rahimi - Piper Sandler & Co., Research Division Jay Olson - Oppenheimer & Co. Inc., Research Division Michael DiFiore - Evercore ISI Institutional Equities, Research Division Akash Tewari - Jefferies LLC, Research Division Thomas Smith - Leerink Partners LLC, Research Division Andrea Tan - Goldman Sachs Group, Inc., …

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image for news Madrigal Pharmaceuticals, Inc. (MDGL) Q3 2025 Earnings Call Transcript
Madrigal (MDGL) Reports Q3 Loss, Tops Revenue Estimates
MDGL
Published: November 04, 2025 by: Zacks Investment Research
Sentiment: Negative

Madrigal (MDGL) came out with a quarterly loss of $5.08 per share versus the Zacks Consensus Estimate of a loss of $1.98. This compares to a loss of $4.92 per share a year ago.

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image for news Madrigal (MDGL) Reports Q3 Loss, Tops Revenue Estimates
Madrigal (MDGL) Expected to Beat Earnings Estimates: Should You Buy?
MDGL
Published: October 28, 2025 by: Zacks Investment Research
Sentiment: Positive

Madrigal (MDGL) possesses the right combination of the two key ingredients for a likely earnings beat in its upcoming report. Get prepared with the key expectations.

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image for news Madrigal (MDGL) Expected to Beat Earnings Estimates: Should You Buy?
Madrigal Pharmaceuticals: Rezdiffra's US And EU Rollout Remains Promising
MDGL
Published: September 30, 2025 by: Seeking Alpha
Sentiment: Positive

MDGL's Rezdiffra is its main value driver. This is the first FDA-approved MASH F2–F3 therapy. So far, Rezdiffra shows a rapid U.S. uptake and market penetration. Management projects over 23,000 patients by Q2 2025. The EU also granted Rezdiffra a conditional authorization. It will soon launch in Germany, and it has a sizeable initial European target of diagnosed F2–F3 patients.

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image for news Madrigal Pharmaceuticals: Rezdiffra's US And EU Rollout Remains Promising
Madrigal Pharmaceuticals, Inc. (MDGL) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference (Transcript)
MDGL
Published: September 08, 2025 by: Seeking Alpha
Sentiment: Neutral

Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL ) Morgan Stanley 23rd Annual Global Healthcare Conference September 8, 2025 7:45 AM EDT Company Participants William Sibold - CEO, President & Director David Soergel - Executive VP & Chief Medical Officer Mardi Dier - Executive VP & CFO Presentation Unknown Analyst Good morning, everyone. Very excited to be kicking off the Morgan Stanley Healthcare Conference with the Madrigal team this morning.

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image for news Madrigal Pharmaceuticals, Inc. (MDGL) Presents At Morgan Stanley 23rd Annual Global Healthcare Conference (Transcript)
Madrigal Gets Conditional Nod for MASH Drug Rezdiffra in EU
MDGL
Published: August 20, 2025 by: Zacks Investment Research
Sentiment: Positive

MDGL wins EU nod for Rezdiffra as the first and only approved MASH therapy. The drug's launch in Europe is expected in the fourth quarter of 2025.

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image for news Madrigal Gets Conditional Nod for MASH Drug Rezdiffra in EU
Madrigal Pharmaceuticals: A High-Paced Launch That Could Grow Further
MDGL
Published: August 15, 2025 by: Seeking Alpha
Sentiment: Positive

Rezdiffra's Q2 '25 net sales surged 55% to $212.8M, beating expectations and highlighting strong commercial momentum for Madrigal Pharmaceuticals, Inc. Despite robust revenue growth, Madrigal Pharmaceuticals still reported a net loss of $42.3M, though profitability may be near. Approval of Rezdiffra in the EU could come in August 2025, with a launch by MDGL in Germany in H2 '25 possible.

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image for news Madrigal Pharmaceuticals: A High-Paced Launch That Could Grow Further
Madrigal Pharmaceuticals to Participate in the Canaccord Genuity 45th Annual Growth Conference
MDGL
Published: August 11, 2025 by: GlobeNewsWire
Sentiment: Neutral

CONSHOHOCKEN, Pa., Aug. 11, 2025 (GLOBE NEWSWIRE) -- Madrigal Pharmaceuticals, Inc. (NASDAQ: MDGL) today announced that the company will participate in the Canaccord Genuity 45th Annual Growth Conference on Tuesday, Aug. 12, 2025 at 10:30 A.M. EDT.

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image for news Madrigal Pharmaceuticals to Participate in the Canaccord Genuity 45th Annual Growth Conference
Madrigal (MDGL) Reports Q2 Loss, Tops Revenue Estimates
MDGL
Published: August 05, 2025 by: Zacks Investment Research
Sentiment: Negative

Madrigal (MDGL) came out with a quarterly loss of $1.9 per share versus the Zacks Consensus Estimate of a loss of $3.48. This compares to a loss of $7.1 per share a year ago.

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image for news Madrigal (MDGL) Reports Q2 Loss, Tops Revenue Estimates
Madrigal Pharmaceuticals Enters into Exclusive Global License Agreement for Oral GLP-1 Receptor Agonist with CSPC Pharmaceutical Group Limited
MDGL
Published: July 30, 2025 by: GlobeNewsWire
Sentiment: Neutral

CONSHOHOCKEN, Pa., July 30, 2025 (GLOBE NEWSWIRE) -- Madrigal Pharmaceuticals, Inc. (NASDAQ: MDGL) (“Madrigal”) today announced that it has entered into an exclusive global license agreement with CSPC Pharmaceutical Group Limited (HKEX Stock CodeL 1093) (“CSPC”) for SYH2086, a preclinical oral small molecule glucagon-like peptide-1 (GLP-1) receptor agonist and orforglipron derivative. Madrigal plans to initiate clinical development in the first half of 2026.

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image for news Madrigal Pharmaceuticals Enters into Exclusive Global License Agreement for Oral GLP-1 Receptor Agonist with CSPC Pharmaceutical Group Limited
MDGL Stock Soars 11% on New Patent Protecting Rezdiffra Dosing Rights
MDGL
Published: July 17, 2025 by: Zacks Investment Research
Sentiment: Positive

Madrigal Pharmaceuticals stock jumps 11% after securing a new U.S. patent for Rezdiffra's dosing, reinforcing exclusivity through 2044.

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image for news MDGL Stock Soars 11% on New Patent Protecting Rezdiffra Dosing Rights
Madrigal (MDGL) Moves 10.9% Higher: Will This Strength Last?
MDGL
Published: July 17, 2025 by: Zacks Investment Research
Sentiment: Positive

Madrigal (MDGL) was a big mover last session on higher-than-average trading volume. The latest trend in earnings estimate revisions might not help the stock continue moving higher in the near term.

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image for news Madrigal (MDGL) Moves 10.9% Higher: Will This Strength Last?
Madrigal Pharmaceuticals to Participate in the 46th Annual Global Goldman Sachs Health Care Conference
MDGL
Published: June 02, 2025 by: GlobeNewsWire
Sentiment: Neutral

CONSHOHOCKEN, Pa., June 02, 2025 (GLOBE NEWSWIRE) -- Madrigal Pharmaceuticals, Inc. (NASDAQ: MDGL) today announced that the company will participate in the 46th Annual Global Goldman Sachs Health Care Conference on Wednesday, June 11, 2025 at 10:40 A.M. EDT.

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image for news Madrigal Pharmaceuticals to Participate in the 46th Annual Global Goldman Sachs Health Care Conference
Madrigal Pharmaceuticals, Inc. (MDGL) Q1 2025 Earnings Call Transcript
MDGL
Published: May 01, 2025 by: Seeking Alpha
Sentiment: Neutral

Madrigal Pharmaceuticals, Inc. (NASDAQ:MDGL ) Q1 2025 Earnings Conference Call May 1, 2025 8:00 AM ET Company Participants Tina Ventura - Chief Investor Relations Officer Bill Sibold - Chief Executive Officer and Director Mardi Dier - Chief Financial Officer Conference Call Participants Eliana Merle - UBS Andrea Newkirk - Goldman Sachs Ritu Baral - TD Cowen Akash Tewari - Jefferies Yasmeen Rahimi - Piper Sandler Liisa Bayko - Evercore Jay Olson - Oppenheimer Mayank Mamtani - B. Riley Securities Prakhar Agrawal - Cantor Fitzgerald Operator Good day, and thank you for standing by.

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image for news Madrigal Pharmaceuticals, Inc. (MDGL) Q1 2025 Earnings Call Transcript
Madrigal Q1 Earnings Beat, MASH Drug Sales Drive Top Line, Stock Up
MDGL
Published: May 01, 2025 by: Zacks Investment Research
Sentiment: Positive

MDGL stock is rising as it reports better-than-expected first-quarter results, beating earnings and revenue estimates, driven by strong Rezdiffra sales.

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image for news Madrigal Q1 Earnings Beat, MASH Drug Sales Drive Top Line, Stock Up
Madrigal (MDGL) Reports Q1 Loss, Tops Revenue Estimates
MDGL
Published: May 01, 2025 by: Zacks Investment Research
Sentiment: Negative

Madrigal (MDGL) came out with a quarterly loss of $3.32 per share versus the Zacks Consensus Estimate of a loss of $3.62. This compares to loss of $7.38 per share a year ago.

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image for news Madrigal (MDGL) Reports Q1 Loss, Tops Revenue Estimates
Madrigal (MDGL) Up 0.5% Since Last Earnings Report: Can It Continue?
MDGL
Published: March 28, 2025 by: Zacks Investment Research
Sentiment: Positive

Madrigal (MDGL) reported earnings 30 days ago. What's next for the stock?

Read More
image for news Madrigal (MDGL) Up 0.5% Since Last Earnings Report: Can It Continue?

About Madrigal Pharmaceuticals, Inc. (MDGL)

  • IPO Date 2007-02-06
  • Website https://www.madrigalpharma.com
  • Industry Biotechnology
  • CEO William J. Sibold
  • Employees 528

Madrigal Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapeutic candidates for the treatment of cardiovascular, metabolic, and liver diseases. Its lead product candidate is resmetirom, a liver-directed selective thyroid hormone receptor-ß agonist, which is in Phase III clinical trials for the treatment of non-alcoholic steatohepatitis. The company also develops MGL-3745, a backup compound to resmetirom. It has research, development, and commercialization agreement with Hoffmann-La Roche. Madrigal Pharmaceuticals, Inc. is headquartered in West Conshohocken, Pennsylvania.