Tempest Therapeutics, Inc. (TPST)

US — Healthcare Sector
Peers: ZIVO  ERAS  FBRX  MDIA  VRPX  RNAZ  INDP  RNXT 

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Key Metrics & Ratings

  • symbol TPST
  • Rev/Share 0.0
  • Book/Share 3.2385
  • PB 2.2726
  • Debt/Equity 1.1771
  • CurrentRatio 1.7024
  • ROIC -1.8561

 

  • MktCap 30083485.0
  • FreeCF/Share -9.9323
  • PFCF -0.8811
  • PE -0.5648
  • Debt/Assets 0.4074
  • DivYield 0
  • ROE -3.0551

 

  • Rating C
  • Score 2
  • Recommendation Sell
  • P/E Score 1
  • DCF Score 3
  • P/B Score 3
  • D/E Score 1

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Downgrade TPST H.C. Wainwright Buy Neutral -- -- April 10, 2025
Downgrade TPST Scotiabank Sector Outperform Sector Perform -- -- April 10, 2025

News

TPST Stock Up on EMA's Orphan Drug Tag for Liver Cancer Therapy
TPST
Published: June 06, 2025 by: Zacks Investment Research
Sentiment: Neutral

Tempest jumps after EMA grants orphan drug status to its liver cancer candidate, amezalpat, based on positive study data.

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image for news TPST Stock Up on EMA's Orphan Drug Tag for Liver Cancer Therapy
Tempest Receives Orphan Drug Designation from the European Medicines Agency for Amezalpat for the Treatment of Patients with HCC
TPST
Published: June 05, 2025 by: GlobeNewsWire
Sentiment: Neutral

EMA Orphan Drug Designation (ODD) builds on U.S. Food & Drug Administration (FDA) ODD and Fast Track Designation, underscoring the urgent need for new treatment options The multiple regulatory designations were granted following strong positive results from a global randomized Phase 1b/2 study in first-line HCC demonstrating superior outcomes for amezalpat combination therapy across multiple study endpoints, including overall survival in both the entire population and key subpopulations, when compared to standard of care alone BRISBANE, Calif., June 05, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage biotechnology company with a pipeline of first-in-class1 targeted and immune-mediated …

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image for news Tempest Receives Orphan Drug Designation from the European Medicines Agency for Amezalpat for the Treatment of Patients with HCC
Tempest Receives Orphan Drug Designation from the FDA for TPST-1495 to Treat Patients with FAP
TPST
Published: April 21, 2025 by: GlobeNewsWire
Sentiment: Neutral

BRISBANE, Calif., April 21, 2025 (GLOBE NEWSWIRE) -- Tempest Therapeutics, Inc. (Nasdaq: TPST), a clinical-stage biotechnology company developing first-in-class1 targeted and immune-mediated therapeutics to fight cancer, today announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation (ODD) to TPST-1495, the company's novel dual receptor inhibitor of prostaglandin (PGE2) signaling, for the treatment of patients with Familial Adenomatous Polyposis (FAP).

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image for news Tempest Receives Orphan Drug Designation from the FDA for TPST-1495 to Treat Patients with FAP

About Tempest Therapeutics, Inc. (TPST)

  • IPO Date 2012-11-12
  • Website https://www.tempesttx.com
  • Industry Biotechnology
  • CEO Stephen R. Brady LLM
  • Employees 24

Tempest Therapeutics Inc., a clinical-stage oncology company, engages in developing small molecule therapeutics to treat cancer. The company's two clinical programs are TPST-1495, a dual antagonist of EP2 and EP4, receptors of prostaglandin E2, and is currently in a Phase 1 trial in solid tumors; and TPST-1120, a selective antagonist of peroxisome proliferator-activated receptor alpha that is in a Phase 1 trial in solid tumors. It also develops TREX-1, a key cellular enzyme that regulates the innate immune response in tumors. The company was founded in 2011 and is headquartered in South San Francisco, California. Tempest Therapeutics Inc. was formerly a subsidiary of Inception Sciences, Inc.