Spero Therapeutics, Inc. (SPRO)

US — Healthcare Sector
Peers: ASMB  ACHL  TIL  NLTX  CTMX  NXTC  NUVB 

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Key Metrics & Ratings

  • symbol SPRO
  • Rev/Share 0.6269
  • Book/Share 0.6106
  • PB 4.6674
  • Debt/Equity 0.1171
  • CurrentRatio 2.5626
  • ROIC -1.4719

 

  • MktCap 159345210.0
  • FreeCF/Share -0.6029
  • PFCF -4.7731
  • PE -2.8234
  • Debt/Assets 0.051
  • DivYield 0
  • ROE -0.9896

 

  • Rating C
  • Score 2
  • Recommendation Sell
  • P/E Score 1
  • DCF Score 1
  • P/B Score 4
  • D/E Score 3

Recent Analyst Ratings

Type Ticker Analyst Firm Previous Rating Current Rating Previous Price Target Current Price Target Date
Downgrade SPRO Evercore ISI Outperform In-line -- $5 Dec. 20, 2024

News

Spero Therapeutics -- Additional Upside Potential Following Positive Phase 3 Results
SPRO
Published: June 11, 2025 by: Seeking Alpha
Sentiment: Positive

Based on the positive results of the registrational Phase 3 PIVOT-PO study, Tebipenem is expected to be approved under the SPA in mid-2026. Spero will not bear any costs or risks since GSK, as a license partner, will take over commercialization. Approval is expected to trigger in total of $175 million in milestone payments over the next 12 months.

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image for news Spero Therapeutics -- Additional Upside Potential Following Positive Phase 3 Results
SPRO Stock Soars 245% on GSK-Partnered UTI Drug Meeting Study Goal
SPRO
Published: May 29, 2025 by: Zacks Investment Research
Sentiment: Positive

SPRO shares surge after GSK-partnered oral drug hits phase III goal early, paving the way for FDA filing and a shift in cUTI treatment options.

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image for news SPRO Stock Soars 245% on GSK-Partnered UTI Drug Meeting Study Goal
Why Is GSK Partner Spero Therapeutics Stock Skyrocketing On Wednesday?
GSK, SPRO
Published: May 28, 2025 by: Benzinga
Sentiment: Positive

GSK plc GSK and Spero Therapeutics Inc SPRO on Wednesday announced that the pivotal phase 3 PIVOT-PO trial evaluating tebipenem HBr for complicated urinary tract infections (cUTIs) will stop early for efficacy.

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image for news Why Is GSK Partner Spero Therapeutics Stock Skyrocketing On Wednesday?
Spero Therapeutics to Present at TD Cowen 45th Annual Health Care Conference
SPRO
Published: February 25, 2025 by: GlobeNewsWire
Sentiment: Neutral

CAMBRIDGE, Mass., Feb. 25, 2025 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO) (Spero), a multi-asset clinical-stage biopharmaceutical company, focused on identifying and developing novel treatments for rare diseases and multi-drug resistant (MDR) bacterial infections, today announced that Esther Rajavelu, Spero's Interim President and Chief Executive Officer, management will present and will be available for one-on-one meetings at the TD Cowen 45th Annual Health Care Conference being held in Boston, March 3rd – 5th, 2025.

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image for news Spero Therapeutics to Present at TD Cowen 45th Annual Health Care Conference

About Spero Therapeutics, Inc. (SPRO)

  • IPO Date 2017-11-02
  • Website https://sperotherapeutics.com
  • Industry Biotechnology
  • CEO Ms. Esther P. Rajavelu
  • Employees 32

Spero Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on identifying, developing, and commercializing treatments for multi-drug resistant (MDR) bacterial infections and rare diseases in the United States. The company's product candidates include tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic to treat complicated urinary tract infections, including pyelonephritis for adults; SPR206, a direct acting IV-administered agent to treat MDR Gram-negative bacterial infections in the hospital; and SPR720, an oral antibiotic for the treatment of non-tuberculous mycobacterial pulmonary disease. It has license agreement with Meiji Seika Pharma Co., Ltd. to support the development of tebipenem HBr; license agreement with Everest Medicines to develop, manufacture, and commercialize SPR206 in Greater China, South Korea, and Southeast Asian countries; collaboration agreement with Bill & Melinda Gates Medical Research Institute to develop SPR720 for the treatment of lung infections caused by Mycobacterium tuberculosis; and license agreement with Vertex Pharmaceuticals Incorporated for patents relating to SPR720, as well as SPR719, an active metabolite. The company was founded in 2013 and is headquartered in Cambridge, Massachusetts.